Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis

Wu, Ming-Yue; Wu, Yang; Zhang, Yong; Liu, Cai-Yun; Deng, Chun-Yan; Peng, Le; Zhou, Lan

doi:10.1186/s12886-017-0442-2

BMC Ophthalmology

Table 1 Characteristics of case–control studies on MMP-9 polymorphisms and glaucoma risk

From: Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis

First author	Year	Country	Racial/descent	Type	Genotyping	Case	Control	Genotype distribution						P for HWE	Source of controls
First author	Year	Country	Racial/descent	Type	Genotyping	Case	Control	Case			Control			P for HWE	Source of controls
rs17576 G > A								G/G	G/A	A/A	G/G	G/A	A/A
Wang	2006	China	Asian	PACG	Applied Biosystems	78	86	17	17	44	38	33	15	0.11	Hospital-based
Aung	2008	Singaporean	Asian	PACG	Applied Biosystems	217	83	135	69	13	48	31	4	0.72	Healthy-based
Cong	2009	China	Asian	PACG	PCR-RFLP	211	205	119	76	16	124	75	6	0.18	Healthy-based
Mossböck1	2010	Austria	Caucasian	POAG	PCR-RFLP	322	248	42	141	139	26	120	102	0.28	Hospital-based
Mossböck2	2010	Austria	Caucasian	XGF	PCR-RFLP	202	248	31	83	88	26	120	102	0.28	Hospital-based
Awadalla	2011	Australian	Caucasian	PACG	Sequenom	104	268	18	49	37	27	109	132	0.52	Population-based
Shi	2013	China	Asian	PACG	Applied Biosystems	231	306	133	78	20	164	113	29	0.15	Population-based
Micheal1	2013	Pakistan	Asian	PACG	PCR-RFLP	82	118	35	32	15	25	53	40	0.34	Healthy-based
Micheal2	2013	Pakistan	Asian	POAG	PCR-RFLP	112	118	38	48	26	25	53	40	0.34	Healthy-based
rs17577 G > A								G/G	G/A	A/A	G/G	G/A	A/A
Wang	2006	China	Asian	PACG	Applied Biosystems	78	86	62	14	2	69	15	2	0.30	Hospital-based
Awadalla	2011	Australian	Caucasian	PACG	Sequenom	106	268	73	29	4	213	51	4	0.64	Population-based
Gao	2014	China	Asian	PACG	PCR-RFLP	214	224	166	44	4	178	43	3	0.83	Hospital-based
rs3918249 C > T								C/C	C/T	T/T	C/C	C/T	T/T
Awadalla	2011	Australian	Caucasian	PACG	Sequenom	106	267	19	49	38	27	109	131	0.54	Population-based
Shi	2013	China	Asian	PACG	Applied Biosystems	231	306	133	79	19	160	116	30	0.19	Population-based
Gao	2014	China	Asian	PACG	PCR-RFLP	213	221	91	109	13	104	103	14	0.08	Hospital-based
rs3918242 C > T								C/C	C/T	T/T	C/C	C/T	T/T
Micheal1	2013	Pakistan	Asian	PACG	PCR-RFLP	82	118	56	25	1	74	37	7	0.42	Healthy-based
Micheal2	2013	Pakistan	Asian	POAG	PCR-RFLP	112	118	70	40	2	74	37	7	0.42	Healthy-based
Markiewicz	2013	Poland	Caucasian	POAG	PCR-RFLP	255	256	166	83	6	195	56	5	0.68	Hospital-based
rs3918254 C > T								C/C	C/T	T/T	C/C	C/T	T/T
Awadalla	2011	Australian	Caucasian	PACG	Sequenom	106	283	105	1	0	282	1	0	0.98	Population-based
Gao	2014	China	Asian	PACG	PCR-RFLP	214	220	125	85	4	122	81	17	0.49	Hospital-based
rs3787268 G > A								G/G	G/A	A/A	G/G	G/A	A/A
Awadalla	2011	Australian	Caucasian	PACG	Sequenom	106	267	64	35	7	174	84	9	0.77	Population-based
Gao	2014	China	Asian	PACG	PCR-RFLP	207	220	82	112	13	89	108	23	0.24	Hospital-based

HWE in control
Test for heterogeneity
NA Not available
AB Applied Biosystems
PCR-RFLP Polymerase chain reaction-restriction fragment length polymorphism
PACG Primary angle-closure glaucoma
POAG Primary open angle glaucoma
XGF Exfoliation glaucoma

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