Skip to main content

Table 3 Summary ORs and 95% CI of MMP-9 polymorphisms and glaucoma risk

From: Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis

 

OR

95% CI

P

I2 (%)a

OR

95% CI

P

I2 (%)a

OR

95% CI

P

I2 (%)a

OR

95% CI

P

I2 (%)a

OR

95% CI

P

I2 (%)a

rs17576 G > A

 

A vs. G

   

GA vs. GG

   

AA vs. GG

   

GA + AA vs. GG

   

AA vs. GG + GA

  

Total

1.10

0.80-1.51

0.56

85.1

0.80

0.67-0.97

0.02

0

1.07

1.07 0.52-2.19

0.86

85.5

0.87

0.60-1.24

0.44

73.7

1.23

0.69-2.18

0.48

85.5

Type

 PACG

1.01

0.62-1.62

0.98

90.6

0.83

0.68-1.03

0.09

16.3

1.10

0.43-2.86

0.84

88.0

0.88

0.56-1.37

0.57

78.9

1.25

0.56-2.85

0.58

87.7

 POAG

0.82

0.51-1.26

0.34

75.8

0.67

0.44-1.01

0.06

0

0.62

0.23-1.61

0.16

54.7

0.66

0.44-0.97

0.03

0

0.84

0.46-1.52

0.56

68.7

 XFG

0.95

0.72-1.25

0.71

NA

0.58

0.32-1.05

0.07

NA

0.90

0.50-1.62

0.29

NA

0.65

0.37-1.13

0.13

NA

1.10

0.76-1.61

0.60

NA

Ethnicity

 Asian

1.27

0.83-1.96

0.27

86.4

0.85

0.68-1.50

0.13

13.0

1.41

0.49-4.06

0.52

88.6

0.98

0.62-1.56

0.94

79.5

1.55

0.60-4.01

0.34

88.2

 Caucasian

0.80

0.50-1.22

0.30

77.5

0.67

0.45-1.00

0.05

0

0.61

0.33-1.12

0.11

52.0

0.66

0.45-0.97

0.03

0

0.81

0.43-1.53

0.52

81.0

Design

 Heal-B

1.08

0.88-1.33

0.46

0

0.79

0.52-1.18

0.25

50.1

1.00

0.26-3.81

1.00

84.7

0.78

0.44-1.37

0.38

76.5

1.14

0.39-3.37

0.81

79.0

 Hosp-B

1.83

0.51-6.54

0.35

96.0

0.77

0.50-1.17

0.22

20.7

2.22

0.28-17.62

0.45

94.6

1.40

0.37-5.35

0.62

90.3

2.51

0.46-13.57

0.27

94.7

 Pop-B

0.76

0.55-1.05

0.10

57.2

0.81

0.58-1.12

0.20

0

0.61

0.31-1.22

0.16

54.7

0.73

0.48-1.12

0.15

35.3

0.68

0.47-0.98

0.04

30.6

Genotyping

 AB

1.40

0.62-3.20

0.42

92.9

0.86

0.65-1.15

0.32

0

1.87

0.48-7.29

0.37

87.3

1.20

0.62-2.30

0.59

80.5

1.93

0.52-7.18

0.32

88.0

 PCR-RFLP

1.05

0.89-1.23

0.57

0

0.74

0.48-1.13

0.16

55.7

0.86

0.32-2.29

0.76

84.1

0.74

0.42-1.30

0.30

77.1

1.05

0.51-2.16

0.89

81.2

rs17577 G > A

 

A vs. G

   

GA vs. GG

   

AA vs. GG

   

GA + AA vs. GG

   

AA vs. GG + GA

  

Total

1.30

0.98-1.72

0.07

12.0

1.26

0.91-1.74

0.16

0

1.79

0.71-4.48

0.22

0

1.30

0.95-1.78

0.10

2.3

1.70

0.68-4.24

0.26

0

Ethnicity

 Asian

1.11

0.78-1.58

0.58

0

1.08

0.72-1.62

0.70

0

1.31

0.39-4.34

0.66

0

1.10

0.78-1.58

0.64

0

1.29

0.39-4.27

0.68

0

Design

 Hosp-B

1.11

0.78-1.58

0.58

0

1.08

0.72-1.62

0.70

0

1.31

0.39-4.34

0.66

0

1.10

0.78-1.58

0.64

0

1.29

0.39-4.27

0.68

0

rs3918249 C > T

 

T vs. C

   

CT vs. CC

   

TT vs. CC

   

CT + TT vs. CC

   

TT vs. CC + CT

  

Total

0.84

0.62-1.14

0.27

67.9

0.91

0.65-1.28

0.59

41.0

0.68

0.46-1.02

0.06

39.9

0.84

0.56-1.47

0.40

63.1

0.71

0.51-0.98

0.04

0

Ethnicity

 Asian

0.96

0.73-1.25

0.75

43.9

0.99

0.68-1.45

0.96

50.9

0.86

0.53-1.40

0.55

0

0.97

0.66-1.42

0.89

55.0

0.87

0.54-1.40

0.58

0

Design

 Heal-B

0.74

0.56-0.98

0.03

41.6

0.77

0.56-1.07

0.12

0

0.57

0.31-1.04

0.07

40.9

0.73

0.54-0.99

0.05

32.7

0.66

0.46-0.95

0.03

0

rs3918242 C > T

 

T vs. C

   

CT vs. CC

   

TT vs. CC

   

CT + TT vs. CC

   

TT vs. CC + CT

  

Total

1.13

0.60-2.13

0.70

82.5

1.37

0.82-2.28

0.23

61.7

0.62

0.11-3.33

0.58

70.5

1.27

0.68-2.36

0.46

78.5

0.57

0.12-2.68

0.48

65.4

Type

 POAG

1.20

0.69-2.06

0.52

73.0

1.51

1.09-2.08

0.01

31.8

0.72

0.16-3.23

0.67

56.2

1.36

0.81-2.28

0.24

59.7

0.65

0.16-2.64

0.55

50.1

Design

 Heal-B

0.81

0.57-1.13

0.22

0

1.02

0.98-1.54

0.91

0

0.25

0.07-0.92

0.04

0

0.92

0.60-1.34

0.60

0

0.25

0.07-0.89

0.03

0

rs3918254 C > T

 

T vs. C

   

CT vs. CC

   

TT vs. CC

   

CT + TT vs. CC

   

TT vs. CC + CT

  

Total

0.80

0.58-1.09

0.15

0

1.04

0.71-1.54

0.83

0

NA

NA

NA

NA

0.90

0.62-1.32

0.60

0

NA

NA

NA

NA

rs3787268 G > A

 

A vs. G

   

GA vs. GG

   

AA vs. GG

   

GA + AA vs. GG

   

AA vs. GG + GA

  

Total

1.06

0.78-1.43

0.72

40.3

1.13

0.83-1.54

0.44

0

1.08

0.32-3.62

0.90

72.7

1.11

0.83-1.50

0.49

0

1.02

0.30-3.51

0.97

75

  1. a Test for heterogeneity
  2. Heal-B Healthy-based
  3. Hosp-B Hospital controls
  4. Pop-B Population controls
  5. NA Not available
  6. AB Applied Biosystems
  7. PCR-RFLP Polymerase chain reaction-restriction fragment length polymorphism
  8. PACG Primary angle-closure glaucoma
  9. POAG Primary open angle glaucoma