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Table 3 The means of subjective discomfort grading, corneal erosion grading, Schirmer test and tear break up time (TBUT) between Group 1 and 2

From: Efficacy and tolerability of preservative-free 0.0015% tafluprost in glaucoma patients: a prospective crossover study

  Group 1 (Taflotan-S® → Taflotan®) Group 2 (Taflotan® → Taflotan-S®)
start 1 month 3 month 6 month 7 month 9 month 12 month start 1 month 3 month 6 month 7 month 9 month 12 month
Subjective discomfort (points) 0.70 ± 0.67 1.87 ± 1.24
p = 0.02*
1.11 ± 1.16
p = 0.31*
0.80 ± 1.39
p = 0.91*
0.50 ± 0.83
p > 0.99*
p = 0.31
0.25 ± 0.46
p > 0.99*
p = 0.10
0.60 ± 0.89
p = 0.78*
p > 0.99
1.33 ± 1.00 1.55 ± 1.66
p = 0.34*
1.85 ± 1.95
p = 0.26*
1.14 ± 0.69
p = 0.24*
1.60 ± 2.07
p = 0.10*
p = 0.56
1.28 ± 1.38
p = 0.11*
p = 0.65
0.87 ± 1.72
p = 0.08*
p = 0.03
Cornea erosion (points) 0.30 ± 0.48 0.25 ± 0.46
p = 0.56*
0.22 ± 0.44
p = 0.56*
0.40 ± 0.51
p = 0.56*
0.50 ± 0.54
p = 0.56*
p > 0.99
0.50 ± 0.53
p = 0.31*
p = 0.65
0.60 ± 0.54
p = 0.31*
p = 0.56
0.55 ± 0.52 0.33 ± 0.50
p = 0.15*
0.28 ± 0.48
p = 0.08*
0.14 ± 0.37
p = 0.15*
0.80 ± 0.83
p > 0.99*
p = 0.15
0.42 ± 0.53
p = 0.56
p > 0.99
0.25 ± 0.46
p = 0.18*
p > 0.99
Schirmer (mm) 5.80 ± 3.88 2.62 ± 2.87
p = 0.20*
4.22 ± 3.15
p = 0.34*
4.60 ± 3.97
p = 0.40*
4.83 ± 6.27
p = 0.34*
p = 0.58
5.37 ± 6.04
p = 0.93*
p = 0.68
4.60 ± 4.56
p = 0.34*
p = 0.78
3.33 ± 3.04 5.66 ± 7.01
p = 0.88*
5.28 ± 3.40
p = 0.22*
5.14 ± 3.67
p = 0.40*
4.40 ± 1.34
p = 0.46*
p = 0.70
6.85 ± 5.04
p = 0.10*
p = 0.25
5.00 ± 3.02
p = 0.23*
p = 0.73
TBUT (sec) 5.80 ± 2.39 3.25 ± 1.28
p = 0.03*
4.33 ± 1.93
p = 0.23*
5.00 ± 1.88
p = 0.32*
4.83 ± 1.16
p = 0.28*
p = 0.71
5.00 ± 2.72
p = 0.73*
p = 0.93
3.60 ± 2.07
p = 0.06*
p = 0.85
4.55 ± 2.18 5.44 ± 2.29
p = 0.16*
5.00 ± 2.23
p = 0.14*
4.42 ± 1.71
p = 0.71*
3.60 ± 0.89
p = 0.15*
p = 0.31
4.14 ± 1.06
p = 0.67*
p = 0.48
4.75 ± 1.83
p = 0.60*
p = 0.52
  1. *comparisons with before using tafloprost (start)
  2. comparisions with the 6 months, in other words, before changing medication