Group 1 (Taflotan-S® → Taflotan®) | Group 2 (Taflotan® → Taflotan-S®) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
start | 1 month | 3 month | 6 month | 7 month | 9 month | 12 month | start | 1 month | 3 month | 6 month | 7 month | 9 month | 12 month | |
Subjective discomfort (points) | 0.70 ± 0.67 | 1.87 ± 1.24 p = 0.02* | 1.11 ± 1.16 p = 0.31* | 0.80 ± 1.39 p = 0.91* | 0.50 ± 0.83 p > 0.99* p = 0.31† | 0.25 ± 0.46 p > 0.99* p = 0.10† | 0.60 ± 0.89 p = 0.78* p > 0.99† | 1.33 ± 1.00 | 1.55 ± 1.66 p = 0.34* | 1.85 ± 1.95 p = 0.26* | 1.14 ± 0.69 p = 0.24* | 1.60 ± 2.07 p = 0.10* p = 0.56† | 1.28 ± 1.38 p = 0.11* p = 0.65† | 0.87 ± 1.72 p = 0.08* p = 0.03† |
Cornea erosion (points) | 0.30 ± 0.48 | 0.25 ± 0.46 p = 0.56* | 0.22 ± 0.44 p = 0.56* | 0.40 ± 0.51 p = 0.56* | 0.50 ± 0.54 p = 0.56* p > 0.99† | 0.50 ± 0.53 p = 0.31* p = 0.65† | 0.60 ± 0.54 p = 0.31* p = 0.56† | 0.55 ± 0.52 | 0.33 ± 0.50 p = 0.15* | 0.28 ± 0.48 p = 0.08* | 0.14 ± 0.37 p = 0.15* | 0.80 ± 0.83 p > 0.99* p = 0.15† | 0.42 ± 0.53 p = 0.56 p > 0.99† | 0.25 ± 0.46 p = 0.18* p > 0.99† |
Schirmer (mm) | 5.80 ± 3.88 | 2.62 ± 2.87 p = 0.20* | 4.22 ± 3.15 p = 0.34* | 4.60 ± 3.97 p = 0.40* | 4.83 ± 6.27 p = 0.34* p = 0.58† | 5.37 ± 6.04 p = 0.93* p = 0.68† | 4.60 ± 4.56 p = 0.34* p = 0.78† | 3.33 ± 3.04 | 5.66 ± 7.01 p = 0.88* | 5.28 ± 3.40 p = 0.22* | 5.14 ± 3.67 p = 0.40* | 4.40 ± 1.34 p = 0.46* p = 0.70† | 6.85 ± 5.04 p = 0.10* p = 0.25† | 5.00 ± 3.02 p = 0.23* p = 0.73† |
TBUT (sec) | 5.80 ± 2.39 | 3.25 ± 1.28 p = 0.03* | 4.33 ± 1.93 p = 0.23* | 5.00 ± 1.88 p = 0.32* | 4.83 ± 1.16 p = 0.28* p = 0.71† | 5.00 ± 2.72 p = 0.73* p = 0.93† | 3.60 ± 2.07 p = 0.06* p = 0.85† | 4.55 ± 2.18 | 5.44 ± 2.29 p = 0.16* | 5.00 ± 2.23 p = 0.14* | 4.42 ± 1.71 p = 0.71* | 3.60 ± 0.89 p = 0.15* p = 0.31† | 4.14 ± 1.06 p = 0.67* p = 0.48† | 4.75 ± 1.83 p = 0.60* p = 0.52† |