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Table 3 The means of subjective discomfort grading, corneal erosion grading, Schirmer test and tear break up time (TBUT) between Group 1 and 2

From: Efficacy and tolerability of preservative-free 0.0015% tafluprost in glaucoma patients: a prospective crossover study

 

Group 1 (Taflotan-S® → Taflotan®)

Group 2 (Taflotan® → Taflotan-S®)

start

1 month

3 month

6 month

7 month

9 month

12 month

start

1 month

3 month

6 month

7 month

9 month

12 month

Subjective discomfort (points)

0.70 ± 0.67

1.87 ± 1.24

p = 0.02*

1.11 ± 1.16

p = 0.31*

0.80 ± 1.39

p = 0.91*

0.50 ± 0.83

p > 0.99*

p = 0.31

0.25 ± 0.46

p > 0.99*

p = 0.10

0.60 ± 0.89

p = 0.78*

p > 0.99

1.33 ± 1.00

1.55 ± 1.66

p = 0.34*

1.85 ± 1.95

p = 0.26*

1.14 ± 0.69

p = 0.24*

1.60 ± 2.07

p = 0.10*

p = 0.56

1.28 ± 1.38

p = 0.11*

p = 0.65

0.87 ± 1.72

p = 0.08*

p = 0.03

Cornea erosion (points)

0.30 ± 0.48

0.25 ± 0.46

p = 0.56*

0.22 ± 0.44

p = 0.56*

0.40 ± 0.51

p = 0.56*

0.50 ± 0.54

p = 0.56*

p > 0.99

0.50 ± 0.53

p = 0.31*

p = 0.65

0.60 ± 0.54

p = 0.31*

p = 0.56

0.55 ± 0.52

0.33 ± 0.50

p = 0.15*

0.28 ± 0.48

p = 0.08*

0.14 ± 0.37

p = 0.15*

0.80 ± 0.83

p > 0.99*

p = 0.15

0.42 ± 0.53

p = 0.56

p > 0.99

0.25 ± 0.46

p = 0.18*

p > 0.99

Schirmer (mm)

5.80 ± 3.88

2.62 ± 2.87

p = 0.20*

4.22 ± 3.15

p = 0.34*

4.60 ± 3.97

p = 0.40*

4.83 ± 6.27

p = 0.34*

p = 0.58

5.37 ± 6.04

p = 0.93*

p = 0.68

4.60 ± 4.56

p = 0.34*

p = 0.78

3.33 ± 3.04

5.66 ± 7.01

p = 0.88*

5.28 ± 3.40

p = 0.22*

5.14 ± 3.67

p = 0.40*

4.40 ± 1.34

p = 0.46*

p = 0.70

6.85 ± 5.04

p = 0.10*

p = 0.25

5.00 ± 3.02

p = 0.23*

p = 0.73

TBUT (sec)

5.80 ± 2.39

3.25 ± 1.28

p = 0.03*

4.33 ± 1.93

p = 0.23*

5.00 ± 1.88

p = 0.32*

4.83 ± 1.16

p = 0.28*

p = 0.71

5.00 ± 2.72

p = 0.73*

p = 0.93

3.60 ± 2.07

p = 0.06*

p = 0.85

4.55 ± 2.18

5.44 ± 2.29

p = 0.16*

5.00 ± 2.23

p = 0.14*

4.42 ± 1.71

p = 0.71*

3.60 ± 0.89

p = 0.15*

p = 0.31

4.14 ± 1.06

p = 0.67*

p = 0.48

4.75 ± 1.83

p = 0.60*

p = 0.52

  1. *comparisons with before using tafloprost (start)
  2. comparisions with the 6 months, in other words, before changing medication