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Table 5 Stratified analysis of the association of SUA on the risk of hypertensive retinopathy (SUA quartiles and as binary variable)

From: Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults

Variable

SUAmg/dl (OR, 95% CI, P value)

Q1

Q2

Q3

Q4

P value for interaction

Non-hyperuricemia

Hyperuricemia

P value for interaction

Gender

    

0.297

  

0.235

 Male

1

0.93 (0.72, 1.22) 0.616

0.96 (0.74, 1.23) 0.721

1.00 (0.77, 1.29) 0.970

 

1

1.06 (0.88, 1.27) 0.531

 

 Female

1

1.01 (0.89, 1.15) 0.877

1.19 (1.03, 1.38) 0.022

1.35 (1.12, 1.63) 0.002

 

1

1.26 (1.09, 1.46) 0.002

 

Age (years)

    

0.026

  

0.149

 < 60

1

1.10 (0.95, 1.27) 0.197

1.12 (0.96, 1.31) 0.149

1.19 (1.00, 1.41) 0.054

 

1

1.38 (1.12, 1.70) 0.003

 

 ≥ 60

1

0.84 (0.70, 1.02) 0.084

1.12 (0.91, 1.39) 0.277

1.28 (1.00, 1.65) 0.054

 

1

1.09 (0.95, 1.26) 0.197

 

Treatment Group

    

0.302

  

0.0301

 Enalapril only

1

1.04 (0.89, 1.23) 0.603

1.12 (0.94, 1.33) 0.215

1.15 (0.94, 1.40) 0.172

 

1

1.05 (0.90, 1.23) 0.509

 

 Enalapril-Folic Acid

1

0.96 (0.81, 1.13) 0.604

1.12 (0.94, 1.34) 0.198

1.29 (1.05, 1.58) 0.016

 

1

1.34 (1.13, 1.58) <0.001

 

SBP (mmHg)

    

0.671

  

0.165

 < 127.0

1

1.04 (0.85, 1.28) 0.715

1.19 (0.96, 1.48) 0.107

1.21 (0.95, 1.54) 0.128

 

1

1.20 (0.99, 1.46) 0.070

 

 ≥ 127.0, <141.3

1

0.93 (0.76, 1.14) 0.469

1.08 (0.87, 1.33) 0.499

1.38 (1.07, 1.77) 0.013

 

1

1.35 (1.10, 1.66) 0.004

 

 ≥ 141.3

1

1.04 (0.85, 1.26) 0.731

1.09 (0.88, 1.35) 0.449

1.08 (0.85, 1.38) 0.533

 

1

1.03 (0.85, 1.25) 0.787

 

DBP (mmHg)

    

0.326

  

0.182

 < 78.0

1

0.99 (0.81, 1.20) 0.893

1.17 (0.95, 1.46) 0.143

1.10 (0.86, 1.39) 0.458

 

1

1.22 (1.00, 1.49) 0.047

 

 ≥ 78.0, <86.5

1

1.06 (0.88, 1.29) 0.523

1.17 (0.95, 1.43) 0.141

1.43 (1.12, 1.83) 0.004

 

1

1.23 (1.01, 1.51) 0.039

 

 ≥ 86.5

1

0.92 (0.74, 1.15) 0.473

0.99 (0.79, 1.24) 0.902

1.09 (0.85, 1.41) 0.485

 

1

1.08 (0.89, 1.32) 0.445

 

DM

    

0.998

  

0.941

 No

1

0.98 (0.86, 1.11) 0.732

1.10 (0.96, 1.27) 0.181

1.15 (0.98, 1.35) 0.097

 

1

1.16 (1.02, 1.32) 0.028

 

 Yes

1

1.05 (0.80, 1.38) 0.716

1.20 (0.90, 1.60) 0.209

1.34 (0.97, 1.85) 0.073

 

1

1.21 (0.93, 1.57) 0.148

 
  1. Abbreviations: SBP Systolic Blood Pressure, DBP Diastolic Blood Pressure, CI confidence interval, OR odds ratio
  2. Q1: <4.4 mg/dl; Q2: 4.4–5.3 mg/dl; Q3: 5.3–6.4 mg/dl; Q4: ≥6.5 mg/dl; DM,diabetes mellitus; Treatment Group: Enalapril only, Enalapril-Folic Acid
  3. Non-hyperuricemia: SUA <7.0 mg/dl in males and SUA <6.0 mg/dl in females; hyperuricemia: SUA ≥7.0 mg/dl in males and SUA ≥6.0 mg/dl in females
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