Table 1 Main characteristics and quality scores of the included studies
Study (year) | Quality score | Study type | Ethnic | Number of cases | Mean age (years) | Treatment | Follow-up (months) | Definition of positive response | Study end points |
|---|---|---|---|---|---|---|---|---|---|
McKibbin (2012) [36] | 7 | Prospective | Caucasian | 104 | 81.5 | RBZ | 6 | >5 BCVA letter score gain after 6Â months | VA (EDTRS) |
Orlin (2012) [37] | 7 | Retrospective | Caucasian | 149 | 80.6 | RBZ or BVZ | 24 | Improved/unchanged VA ≥ 24 months | VA (Snellen) |
Abedi (2013) [38] | 7 | Prospective | Caucasian | 210 | 78 | RBZ or BVZ | 12 | <15 letters lose after 12Â months | VA (EDTRS) |
Hagstrom (2013) [37] | 7 | Prospective | Caucasian | 834 | 78.5 | RBZ or BVZ | 12 | ≥15 letter gain from baseline | VA (EDTRS) |
Park (2014) [40] | 8 | Prospective | East Asia | 273 | 69.5 | RBZ | 5 | ≥8 letter gain at 5 months | VA (EDTRS) |