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Fig. 2 | BMC Ophthalmology

Fig. 2

From: A novel TRPM8 agonist relieves dry eye discomfort

Fig. 2

Pharmacological activities of 1-dialkylphosphorylalkanes (Dapa). (a) Relative potencies of Dapa to menthol in TRPM8 assay. The number on the abscissa represent the n-alkyl side-chain of 4–5–6-7-8-9-10 carbons, corresponding to a butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl group, respectively. (b, c, d) Shaking frequency of anesthetized rats (n = 3 to 6 per group) is counted for 15 min, 40 min, and 1 h after intravenous 2 mg/kg, perioral 20 mg/kg, or topical 20 μL application of Dapa. From this pattern of response, C3 (the nonyl analogue) is selected as the lead candidate. The term x Menthol on the ordinate of Fig. 2a is potency relative to I-menthol, wherein menthol = 1

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