Fig. 4From: A novel TRPM8 agonist relieves dry eye discomfortTear secretion in dry eye mice is increased via application of C3 on upper eyelid. (a) Tear secretion is increased via topical application of C3 compared to the vehicle (saline), both in sham group (5.4 ± 0.5 vs. 3.8 ± 0.5, n = 5) and dry eye mice (1.3 ± 0.4 vs. 0.5 ± 0.1, n = 6). (b, c) Spontaneous blinking and corneal abrasion are not affected by vehicle or C3 application in sham group or dry eye mouse model. All data are presented as means ± SEM. Statistical significances were calculated using t-test. *P < 0.05. **P < 0.01Back to article page