Identification of pathogenic genes and upstream regulators in age-related macular degeneration

BMC Ophthalmology

Table 3 Top 30 most significantly up- or down-regulated genes in AMD

GeneId	Symbol	Combined.ES	P.Value	FDR	Regulation
3371	TNC	0.583092249	4.83E-07	0.002942856	Up
341	APOC1	0.56999013	8.86E-07	0.002942856	Up
54,742	LY6K	−0.568356126	9.64E-07	0.002942856	Down
10,647	SCGB1D2	0.564849096	1.05E-06	0.002942856	Up
84,624	FNDC1	0.542691118	2.64E-06	0.005012426	Up
2922	GRP	0.543254919	2.67E-06	0.005012426	Up
11,096	ADAMTS5	0.542022774	2.72E-06	0.005012426	Up
146,802	SLC47A2	0.5296511	4.48E-06	0.006043125	Up
55,652	SLC48A1	0.529070013	4.69E-06	0.006043125	Up
5803	PTPRZ1	0.520669191	6.49E-06	0.007684835	Up
2191	FAP	0.51940808	6.88E-06	0.007684835	Up
7189	TRAF6	−0.517257899	7.61E-06	0.007741325	Down
6720	SREBF1	0.514810439	8.35E-06	0.007779644	Up
7158	TP53BP1	−0.504884978	1.20E-05	0.010594686	Down
64,111	NPVF	0.50028869	1.45E-05	0.011148798	Up
23,336	SYNM	0.501243284	1.47E-05	0.011148798	Up
116,238	TLCD1	0.498263445	1.53E-05	0.011148798	Up
2878	GPX3	0.496829715	1.64E-05	0.011475202	Up
414,328	C9orf103	0.483245526	2.70E-05	0.017394853	Up
79,047	KCTD15	−0.48163493	2.90E-05	0.018035511	Down
199,974	CYP4Z1	−0.47837158	3.37E-05	0.019718857	Down
3475	IFRD1	−0.477678809	3.41E-05	0.019718857	Down
8334	HIST1H2AC	−0.467574449	4.95E-05	0.026761718	Down
84,269	CHCHD5	0.463229503	5.82E-05	0.029154389	Up
949	SCARB1	0.464706572	5.91E-05	0.029154389	Up
7101	NR2E1	0.46403246	6.20E-05	0.029680373	Up
5393	EXOSC9	0.458296775	6.96E-05	0.030872051	Up
10,219	KLRG1	−0.454787798	7.61E-05	0.031906258	Down
23,090	ZNF423	−0.451945937	8.69E-05	0.034135755	Down
57,097	PARP11	−0.450396437	8.96E-05	0.034135755	Down

ISSN: 1471-2415