From: Identification of pathogenic genes and upstream regulators in age-related macular degeneration
Items | Items_Details | Count | P_value | FDR | Genes |
---|---|---|---|---|---|
Kegg:00280 | Valine, leucine and isoleucine degradation | 12 | 4.19E-08 | 8.51E-06 | ACAT2,ALDH3A2,BCAT1,HMGCS1,BCKDHB,BCKDHA,ALDH9A1,HMGCL,ACADSB,IL4I1,PCCB,ALDH2 |
Kegg:00100 | Steroid biosynthesis | 8 | 1.74E-07 | 1.77E-05 | DHCR7,FDFT1,CYP27B1,TM7SF2,SQLE,SOAT2,DHCR24,EBP |
Kegg:04310 | Wnt signaling pathway | 18 | 1.02E-05 | 0.000516 | LRP5,LEF1,NLK,CAMK2B,PRKCB,NFATC3,CSNK1E,PRKCG,FZD5,PPP2R5C,SFRP2,FZD9,APC,CTNNBIP1,ROCK1,DKK1,APC2,MMP7 |
Kegg:00900 | Terpenoid backbone biosynthesis | 6 | 9.28E-06 | 0.000628 | ACAT2,HMGCS1,MVK,GGPS1,IDI1,FDPS |
Kegg:05322 | Systemic lupus erythematosus | 13 | 1.99E-05 | 0.00081 | HIST1H2BM,HIST1H2BJ,HIST1H2BD,C5,HIST1H2BL,HIST1H2BH,CTSG,CD86,HIST1H2AC,HIST3H2A,HIST1H2AE,HIST1H2BB,HIST1H2BO |
Kegg:04080 | Neuroactive ligand-receptor interaction | 24 | 6.26E-05 | 0.002118 | P2RY2,GABRB1,CHRNA3,ADRB1,GCGR,GABRE,TBXA2R,GRM7,BDKRB2,CALCRL,NMBR,NPY1R,HRH3,SSTR1,GRM5,CTSG,CHRNA10,MC3R,GRIK3,GABRP,RXFP1,TACR3,CRHR1,ADORA1 |
Kegg:04020 | Calcium signaling pathway | 18 | 8.83E-05 | 0.002242 | ADRB1,CAMK2B,TBXA2R,BDKRB2,PRKCB,MYLK,PRKCG,GRM5,ERBB4,ADCY7,ITPKA,PLCZ1,SLC25A4,NOS3,TACR3,PHKG1,RYR1,PDE1A |
Kegg:05200 | Pathways in cancer | 27 | 7.78E-05 | 0.002255 | FH,LEF1,RARB,PIAS2,FGF1,PRKCB,RUNX1T1,PRKCG,NRAS,TGFB3,CDKN2B,FZD5,TGFB2,EGF,TRAF6,FZD9,APC,GSTP1,HSP90B1,HDAC1,PAX8,MAP2K1,PPARG,STAT5B,CBL,APC2,RALGDS |
Kegg:00330 | Arginine and proline metabolism | 9 | 0.000145 | 0.003266 | ALDH3A2,ADC,ALDH9A1,ARG1,NOS3,GOT2,AMD1,ALDH4A1,ALDH2 |
Kegg:04350 | TGF-beta signaling pathway | 11 | 0.000207 | 0.004199 | BMP7,COMP,BMPR1B,TGFB3,ID1,CDKN2B,SMURF2,TGFB2,THBS4,ROCK1,ZFYVE9 |
Kegg:04012 | ErbB signaling pathway | 11 | 0.00035 | 0.006461 | CAMK2B,PRKCB,PRKCG,NRAS,EREG,ERBB4,EGF,PAK3,MAP2K1,STAT5B,CBL |
Kegg:00310 | Lysine degradation | 8 | 0.00039 | 0.006594 | ACAT2,ALDH3A2,PIPOX,WHSC1L1,ALDH9A1,SETD8,GLT25D2,ALDH2 |
Kegg:04146 | Peroxisome | 10 | 0.000466 | 0.00727 | PAOX,PIPOX,SLC27A2,MVK,AGXT,PEX7,HMGCL,NUDT12,PEX10,AMACR |
Kegg:04142 | Lysosome | 13 | 0.000534 | 0.007738 | MCOLN1,NAGPA,SCARB2,CTSF,CTSL2,ARSA,CTSG,LAMP1,ATP6AP1,SORT1,LAPTM4B,ABCB9,AP3S1 |
Kegg:01040 | Biosynthesis of unsaturated fatty acids | 5 | 0.000836 | 0.009981 | PTPLB,FADS2,SCD,ACOT1,FADS1 |