Skip to main content

Table 4 The top 15 most significantly enriched pathways in AMD

From: Identification of pathogenic genes and upstream regulators in age-related macular degeneration

Items

Items_Details

Count

P_value

FDR

Genes

Kegg:00280

Valine, leucine and isoleucine degradation

12

4.19E-08

8.51E-06

ACAT2,ALDH3A2,BCAT1,HMGCS1,BCKDHB,BCKDHA,ALDH9A1,HMGCL,ACADSB,IL4I1,PCCB,ALDH2

Kegg:00100

Steroid biosynthesis

8

1.74E-07

1.77E-05

DHCR7,FDFT1,CYP27B1,TM7SF2,SQLE,SOAT2,DHCR24,EBP

Kegg:04310

Wnt signaling pathway

18

1.02E-05

0.000516

LRP5,LEF1,NLK,CAMK2B,PRKCB,NFATC3,CSNK1E,PRKCG,FZD5,PPP2R5C,SFRP2,FZD9,APC,CTNNBIP1,ROCK1,DKK1,APC2,MMP7

Kegg:00900

Terpenoid backbone biosynthesis

6

9.28E-06

0.000628

ACAT2,HMGCS1,MVK,GGPS1,IDI1,FDPS

Kegg:05322

Systemic lupus erythematosus

13

1.99E-05

0.00081

HIST1H2BM,HIST1H2BJ,HIST1H2BD,C5,HIST1H2BL,HIST1H2BH,CTSG,CD86,HIST1H2AC,HIST3H2A,HIST1H2AE,HIST1H2BB,HIST1H2BO

Kegg:04080

Neuroactive ligand-receptor interaction

24

6.26E-05

0.002118

P2RY2,GABRB1,CHRNA3,ADRB1,GCGR,GABRE,TBXA2R,GRM7,BDKRB2,CALCRL,NMBR,NPY1R,HRH3,SSTR1,GRM5,CTSG,CHRNA10,MC3R,GRIK3,GABRP,RXFP1,TACR3,CRHR1,ADORA1

Kegg:04020

Calcium signaling pathway

18

8.83E-05

0.002242

ADRB1,CAMK2B,TBXA2R,BDKRB2,PRKCB,MYLK,PRKCG,GRM5,ERBB4,ADCY7,ITPKA,PLCZ1,SLC25A4,NOS3,TACR3,PHKG1,RYR1,PDE1A

Kegg:05200

Pathways in cancer

27

7.78E-05

0.002255

FH,LEF1,RARB,PIAS2,FGF1,PRKCB,RUNX1T1,PRKCG,NRAS,TGFB3,CDKN2B,FZD5,TGFB2,EGF,TRAF6,FZD9,APC,GSTP1,HSP90B1,HDAC1,PAX8,MAP2K1,PPARG,STAT5B,CBL,APC2,RALGDS

Kegg:00330

Arginine and proline metabolism

9

0.000145

0.003266

ALDH3A2,ADC,ALDH9A1,ARG1,NOS3,GOT2,AMD1,ALDH4A1,ALDH2

Kegg:04350

TGF-beta signaling pathway

11

0.000207

0.004199

BMP7,COMP,BMPR1B,TGFB3,ID1,CDKN2B,SMURF2,TGFB2,THBS4,ROCK1,ZFYVE9

Kegg:04012

ErbB signaling pathway

11

0.00035

0.006461

CAMK2B,PRKCB,PRKCG,NRAS,EREG,ERBB4,EGF,PAK3,MAP2K1,STAT5B,CBL

Kegg:00310

Lysine degradation

8

0.00039

0.006594

ACAT2,ALDH3A2,PIPOX,WHSC1L1,ALDH9A1,SETD8,GLT25D2,ALDH2

Kegg:04146

Peroxisome

10

0.000466

0.00727

PAOX,PIPOX,SLC27A2,MVK,AGXT,PEX7,HMGCL,NUDT12,PEX10,AMACR

Kegg:04142

Lysosome

13

0.000534

0.007738

MCOLN1,NAGPA,SCARB2,CTSF,CTSL2,ARSA,CTSG,LAMP1,ATP6AP1,SORT1,LAPTM4B,ABCB9,AP3S1

Kegg:01040

Biosynthesis of unsaturated fatty acids

5

0.000836

0.009981

PTPLB,FADS2,SCD,ACOT1,FADS1