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Table 2 Oxidative Stress Related Genes with miRNA Targets in Cataractous Samples

From: MiRNAs regulate oxidative stress related genes via binding to the 3′ UTR and TATA-box regions: a new hypothesis for cataract pathogenesis

Gene Symbol

Pro-oxidant(a)

Anti-oxidant(a)

Regulation

Average fold change(b)

ALDH1A3

N

Y

down

0.50

FTL

N

Y

down

0.50

MT1E

N

Y

down

0.50

MT1G

N

Y

down

0.32

MT1H

N

Y

down

0.50

MT1M

N

Y

down

0.15

PRDX4

N

Y

down

0.50

SOD1

N

Y

down

0.50

TF

N

Y

down

0.17

TXN

N

Y

down

0.50

CYB5A

Y

N

up

2.00

CYCS

Y

N

up

2.73

CYP1A2

Y

N

up

2.00

CYP1B1

Y

N

up

7.11

TXNIP

Y

N

up

6.36

  1. (a) “Y” = yes; “N” = no
  2. (b) Average fold change values were means of 3 separate array results (fold change = cataractous lens sample/transparent lens sample)
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BMC Ophthalmology

ISSN: 1471-2415

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