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Table 2 Univariate analysis for preserved vs. geographic atrophy/fibrotic scar

From: Predictive models of long-term anatomic outcome in age-related macular degeneration treated with as-needed Ranibizumab

 

Baseline

3 months

n (%)

OR

CI 95%

p-value

n (%)

OR

IC 95%

p-value

Age

194

0.9473

0.9058

0.9907

0.018

-

-

-

-

-

Sex

 Female

116 (59.79)

1

-

-

-

-

-

-

-

-

 Male

78 (40.21)

0.7211

0.3506

0.1.4829

0.374

-

-

-

-

-

Year of diagnosis

 2007

4 (2.06)

0.619

0.0588

6.5209

0.6897

-

-

-

-

-

 2008

49 (25.26)

0.4762

0.1839

1.2328

0.1263

-

-

-

-

-

 2009

101 (52.06)

0.3496

0.1508

0.8106

0.0143

-

-

-

-

-

 2010

40 (20.62)

1

-

-

-

-

-

-

-

-

Delay of treatment

  < 30 days

128 (65.98)

1

-

-

-

-

-

-

-

-

 (30–90] days

50 (25.77)

0.5557

0.226

1.3664

0.2006

-

-

-

-

-

  > 90 days

16 (8.25)

1.5517

0.4986

4.8289

0.4481

-

-

-

-

-

Angiographic type of lesion

 Classic

43 (31.85)

0.5147

0.1925

1.3759

0.1855

-

-

-

-

-

 Predominantly classic

13 (9.63)

0.4813

0.0965

2.3997

0.3723

-

-

-

-

-

 Minimally classic

14 (10.37)

0.2036

0.0247

1.678

0.1391

-

-

-

-

-

 Occult

62 (45.93)

1

-

-

-

-

-

-

-

-

 Others

3 (2.22)

1.3235

0.1126

15.5608

0.8236

-

-

-

-

-

Status of the fellow eye

 Initial/intermediate AMD

75 (40.76)

1

-

-

-

-

-

-

-

-

 Neovascular

13 (7.07)

1.1429

0.3174

4.115

0.8381

-

-

-

-

-

 Atrophic

38 (20.65)

0.1429

0.0315

0.6469

0.0116

-

-

-

-

-

 Disciform scar

37 (20.11)

0.6

0.2286

1.5746

0.2994

-

-

-

-

-

 Others

21 (11.41)

1.0286

0.3519

3.0064

0.9589

-

-

-

-

-

Status of the lens

 Cataract

108 (64.29)

1

-

-

-

-

-

-

-

-

 Pseudophakia

53 (31.55)

1.43

0.6477

3.1572

0.3761

-

-

-

-

-

 Transparent

7 (4.17)

5.8667

1.216

28.3039

0.0276

-

-

-

-

-

BCVA

194

0.1296

0.0477

0.3517

0.0001

194

0.0668

0.0194

0.2301

<0.0001

CMT change

-

-

-

-

-

191

0.8438

0.2975

2.3933

0.7496

OCT assessment

 SRF

49 (28)

0.4263

0.0917

1.9823

0.2769

60 (31.91)

1.3636

0.6457

2.8796

0.4161

 Thickening

21 (12)

4.05

0.5372

30.5344

0.1748

7 (3.72)

-

-

-

0.9867

 Both

101 (57.71)

1

-

-

-

9 (4.79)

0.5114

0.0607

4.3051

0.5372

 None

4 (2.29)

1.7868

0.819

3.8982

0.1448

112 (59.57)

1

-

-

-

Macular associated lesions

 Bleeding >50%

20 (14.6)

0.402

0.1046

1.5454

0.1847

5 (4.24)

0.6964

0.0716

6.7734

0.7553

 PED

37 (27.01)

0.3559

0.1193

1.0621

0.064

23 (19.49)

0.2653

0.055

1.28

0.0984

 RPE tear

2 (1.46)

-

-

-

0.9969

3 (2.54)

-

-

-

0.9976

 Initial minimal atrophy

5 (3.65)

-

-

-

0.9951

8 (6.78)

-

-

-

0.9961

 Initial minimal fibrosis

10 (7.3)

-

-

-

0.9931

23 (19.49)

-

-

-

0.9934

 RAP

2 (1.46)

2.2778

0.1349

38.4694

0.5681

2 (1.69)

2.7857

0.163

47.597

0.4793

 PV

2 (1.46)

-

-

-

0.9969

1 (0.85)

-

-

-

0.9985

 Others

59 (43.07)

-

-

-

-

53 (44.92)

-

-

-

-

Total time of treatment

-

-

-

-

-

-

-

-

-

-

Number of injections

-

-

-

-

-

194

1.9616

0.9564

4.0233

0.066

Number of visits

-

-

-

-

-

170

1.4041

0.8748

2.2536

0.1598

 

1 year

2 years

n (%)

OR

CI 95%

p-value

n (%)

OR

CI 95%

p-value

Age

-

-

-

-

-

-

-

-

-

-

Sex

 Female

-

-

-

-

-

-

-

-

-

-

 Male

-

-

-

-

-

-

-

-

-

-

Year of diagnosis

 2007

-

-

-

-

-

-

-

-

-

-

 2008

-

-

-

-

-

-

-

-

-

-

 2009

-

-

-

-

-

-

-

-

-

-

 2010

-

-

-

-

-

-

-

-

-

-

Delay of treatment

 < 30 days

-

-

-

-

-

-

-

-

-

-

 (30–90] days

-

-

-

-

-

-

-

-

-

-

 > 90 days

-

-

-

-

-

-

-

-

-

-

Angiographic type of lesion

 Classic

-

-

-

-

-

-

-

-

-

-

 Predominantly classic

-

-

-

-

-

-

-

-

-

-

 Minimally classic

-

-

-

-

-

-

-

-

-

-

 Occult

-

-

-

-

-

-

-

-

-

-

 Others

-

-

-

-

-

-

-

-

-

-

Status of the fellow eye

 Initial/intermediate AMD

-

-

-

-

-

-

-

-

-

-

 Neovascular

-

-

-

-

-

-

-

-

-

-

 Atrophic

-

-

-

-

-

-

-

-

-

-

 Disciform

-

-

-

-

-

-

-

-

-

-

 Others

-

-

-

-

-

-

-

-

-

-

Status of the fellow eye

          

 Cataract

-

-

-

-

-

-

-

-

-

-

 Pseudophakia

-

-

-

-

-

-

-

-

-

-

 Transparent

-

-

-

-

-

-

-

-

-

-

BCVA

194

0.0227

0.0058

0.0891

<0.0001

194

0.0694

0.026

0.1851

<0.0001

CMT change

192

0.5216

0.1953

1.3932

0.1941

192

1.3015

0.5533

3.0618

0.546

OCT assessment

 SRF

52 (27.96)

0.6667

0.2882

1.542

0.2769

33 (18.33)

1.5

0.6232

3.6105

0.3656

 Thickening

11 (5.91)

0.7078

0.1441

3.478

0.1748

6 (3.33)

2

0.3472

11.52

0.4378

 Both

10 (5.38)

0.3539

0.0429

2.9208

-

11 (6.11)

0.8889

0.181

4.3646

0.8847

 None

113 (60.75)

1

-

-

0.1448

130 (72.22)

1

-

-

-

Macular associated lesions

 Bleeding >50%

1 (0.76)

-

-

.

0.9986

1 (0.75)

-

-

-

0.9986

 PED

17 (12.88)

0.0882

0.0107

0.7305

0.0244

18 (13.43)

0.2267

0.0547

0.9385

0.0406

 RPE tear

4 (3.03)

0.4706

0.045

4.9191

0.529

2 (1.49)

-

-

-

0.998

 Initial minimal atrophy

22 (16.67)

0.1412

0.0291

0.6859

0.0152

26 (19.4)

-

-

-

0.9926

 Initial minimal fibrosis

47 (33.61)

-

-

-

0.9902

54 (40.3)

0.0436

0.009

0.2103

0.0001

 RAP

0 (0)

-

-

-

-

0 (0)

-

-

-

-

 PV

0 (0)

-

-

-

-

1 (0.75)

-

-

-

0.9986

 Others

41 (31.06)

1

-

-

-

32 (23.88)

1

-

-

-

Total time of treatment

-

-

-

-

-

-

-

-

-

-

Number of injections

194

1.2133

0.9583

1.5362

-

189

1.1721

0.9163

1.4992

0.2062

Number of visits

184

1.1135

0.9391

1.3202

-

187

1.0613

0.9327

1.2076

0.3666

 

3 years

4 years

n (%)

OR

CI 95%

p-value

n (%)

OR

CI 95%

p-value

Age

-

-

-

-

-

-

-

-

-

-

Sex

 Female

-

-

-

-

-

-

-

-

-

-

 Male

-

-

-

-

-

-

-

-

-

-

Year of diagnosis

 2007

-

-

-

-

-

-

-

-

-

-

 2008

-

-

-

-

-

-

-

-

-

-

 2009

-

-

-

-

-

-

-

-

-

-

 2010

-

-

-

-

-

-

-

-

-

-

Delay of treatment

 < 30 days

-

-

-

-

-

-

-

-

-

-

 (30–90] days

-

-

-

-

-

-

-

-

-

-

 > 90 days

-

-

-

-

-

-

-

-

-

-

Angiographic type of lesion

 Classic

-

-

-

-

-

-

-

-

-

-

 Predominantly classic

-

-

-

-

-

-

-

-

-

-

 Minimally classic

-

-

-

-

-

-

-

-

-

-

 Occult

-

-

-

-

-

-

-

-

-

-

 Others

-

-

-

-

-

-

-

-

-

-

Status of the fellow eye

 Initial/intermediate AMD

-

-

-

-

-

50 (27.17)

1

-

-

-

 Neovascular

-

-

-

-

-

21 (11.41)

0.075

0.0093

0.6042

0.015

 Atrophic

-

-

-

-

-

50 (27.17)

0.1304

0.0406

0.4194

0.0006

 Disciform scar

-

-

-

-

-

44 (23.91)

0.3857

0.1529

0.9733

0.0437

 Others

-

-

-

-

-

19 (10.33)

0.6923

0.2257

2.1232

0.5201

Status of the lens

 Cataract

-

-

-

-

-

-

-

-

-

-

 Pseudophakia

-

-

-

-

-

-

-

-

-

-

 Transparent

-

-

-

-

-

-

-

-

-

-

BCVA

194

0.0523

0.0182

0.1501

<0.0001

194

0.0595

0.0219

0.1616

<0.0001

CMT change

192

1.2116

0.5475

2.6811

0.6358

192

1.3213

0.6428

2.7159

0.4485

OCT assessment

 SRF

19 (14.62)

0.9576

0.2885

3.1789

0.9435

5 (7.68)

-

-

-

0.9926

 Thickening

5 (3.85)

0.8977

0.0954

8.4467

0.9248

1 (1.52)

-

-

-

0.9962

 Both

5 (3.85)

5.3864

0.8465

34.2744

0.0745

3 (4.55)

1.5357

0.1292

18.248

0.7341

 None

101 (77.69)

1

-

-

-

57 (86.36)

1

-

-

-

Macular associated lesions

 Bleeding >50%

0 (0)

-

-

-

-

0 (0)

-

-

-

-

 PED

9 (8.65)

0.1136

0.012

1.0764

0.058

1 (1.82)

-

-

-

0.9963

 RPE tear

3 (2.28)

-

-

-

0.9975

1 (1.82)

-

-

-

0.9963

 Initial minimal atrophy

26 (25)

-

-

-

0.9926

13 (23.64)

0.0417

0.0035

0.4908

0.0115

 Initial minimal fibrosis

45 (43.27)

0.0423

0.0081

0.2216

0.0002

31 (56.36)

0.0167

0.0015

0.1887

0.0009

 RAP

0 (0)

-

-

-

-

0 (0)

-

-

-

-

 PV

0 (0)

-

-

-

-

0 (0)

-

-

-

-

 Others

21 (20.19)

1

-

-

-

9 (16.36)

1

-

-

-

Total time of treatment

-

-

-

-

-

194

1.0131

0.982

1.0453

0.4134

Number of injections

147

1.0238

0.8646

1.2122

0.7852

71

1.0032

0.8306

1.2116

0.9738

Number of visits

147

1.1359

0.9571

1.3482

0.1448

76

0.9568

0.7498

1.2211

0.7229

  1. A total of 194 patients were included in the final univariate analysis for presence of preserved macula vs. geographic atrophy/fibrotic scar. This table shows all the variables evaluated in each visit during the 4 years of follow-up. OR: odds ratio, CI: confidence interval, AMD: age-related macular degeneration, BCVA: best corrected visual acuity, CMT: central macular thickness, SRF: subretinal fluid, PED: pigment epithelium detachment, RPE: retinal pigment epithelium, RAP: retinal angiomatous proliferation, PV: polypoidal vasculopathy. Statistically significant results appear in italic
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BMC Ophthalmology

ISSN: 1471-2415

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