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Table 3 Univariate analysis for geographic atrophy vs. fibrotic scar

From: Predictive models of long-term anatomic outcome in age-related macular degeneration treated with as-needed Ranibizumab

 

Baseline

3 months

n (%)

OR

CI 95%

p-value

n (%)

OR

CI 95%

p-value

Age

153

1.0119

0.9678

1.058

0.6024

-

-

-

-

-

Sex

 Female

89 (58.17)

1

-

-

-

-

-

-

-

-

 Male

64 (41.83)

0.4579

0.2368

0.8857

0.0203

-

-

-

-

-

Year of diagnosis

 2007

3 (1.96)

0.9444

0.075

11.8891

0.9647

-

-

-

-

-

 2008

39 (25.49)

1.314

0.4693

3.6789

0.6031

-

-

-

-

-

 2009

85 (55.56)

2.2279

0.8935

5.5553

0.0857

-

-

-

-

-

 2010

26 (16.99)

1

-

-

-

-

-

-

-

-

Delay of treatment

  < 30 days

99 (64.71)

1

-

-

-

-

-

-

-

-

 (30–90] days

43 (28.1)

0.8411

0.4097

1.7271

0.6374

-

-

-

-

-

  > 90 days

11 (7.19)

0.8854

0.2535

3.0921

0.8487

-

-

-

-

-

Angiographic type of lesion

 Classic

36 (33.64)

1.1957

0.4961

2.8816

0.6905

-

-

-

-

-

 Predominantly classic

11 (10.28)

0.3587

0.0841

1.5291

0.1658

-

-

-

-

-

 Minimally classic

13 (12.15)

0.5978

0.1694

2.1097

0.4239

-

-

-

-

-

 Occult

45 (42.06)

1

-

-

-

-

-

-

-

-

 Others

2 (1.87)

-

-

-

0.9879

-

-

-

-

-

Status of the fellow eye

 Initial/intermediate AMD

54 (37.5)

1

-

-

-

-

-

-

-

-

 Neovascular

9 (6.25)

4.375

0.8314

23.0235

0.1015

-

-

-

-

-

 Atrophic

36 (25)

0.8929

0.3806

2.0947

0.7945

-

-

-

-

-

 Disciform scar

30 (20.83)

1.25

0.511

3.0579

0.6249

-

-

-

-

-

 Others

15 (10.42)

0.625

0.1882

2.0755

0.4428

-

-

-

-

-

Status of the lens

 Cataract

88 (67.18)

1

-

-

-

-

-

-

-

-

 Pseudophakia

40 (30.53)

1.1679

0.5516

2.4728

0.6851

-

-

-

-

-

 Transparent

3 (2.29)

1.9111

0.1671

21.8512

0.6024

-

-

-

-

-

BCVA

153

0.8892

0.4752

1.6636

0.7132

153

1.0638

0.5598

2.0217

0.8502

CMT change

-

-

-

-

-

150

1.4185

0.5473

3.677

0.4718

OCT assessment

 SRF

34 (25)

1.25

0.5603

2.7889

0.5858

45 (30)

1.4286

0.6966

2.9297

0.3304

 Thickening

19 (13.97)

0.9091

0.3309

2.4976

0.8534

7 (4.67)

1.6667

0.3525

7.8809

0.5193

 Both

81 (59.56)

1

-

-

-

8 (5.33)

0.1786

0.0211

1.5119

0.1139

 None

2 (1.47)

1.25

0.0755

20.6845

0.8762

90 (60)

1

-

-

-

Macular associated lesions

 Bleeding >50%

17 (15.45)

0.8466

0.2729

2.6266

0.7731

4 (4.04)

0.2857

0.0273

2.9932

0.2959

 PED

32 (29.09)

1.2245

0.4837

3.1

0.6691

21 (21.21)

0.6429

0.2207

1.8728

0.418

 RPE tear

2 (1.82)

-

-

-

0.9922

3 (3.03)

1.7143

0.1433

20.504

0.6703

 Initial minimal atrophy

5 (4.55)

1.4286

0.2156

9.4665

0.7119

8 (8.08)

2.5714

0.4606

14.355

0.2817

 Initial minimal fibrosis

10 (9.09)

0.2381

0.045

1.2599

0.0914

23 (23.23)

0.3025

0.0983

0.9306

0.037

 RAP

1 (0.91)

-

-

-

0.9945

1 (1.01)

-

-

-

0.9914

 PV

2 (1.82)

-

-

-

0.9922

0 (0)

-

-

-

-

 Others

41 (37.27)

1

-

-

-

39 (39.39)

1

-

-

-

Total time of treatment

-

-

-

-

-

-

-

-

-

-

Number of injections

-

-

-

-

-

153

2.5099

1.318

4.7796

0.0051

Number of visits

-

-

-

-

-

133

0.9856

0.6336

1.5332

0.9486

 

1 year

2 years

n (%)

OR

CI 95%

p-value

n (%)

OR

CI 95%

p-value

Age

-

-

-

-

-

-

-

-

-

-

Sex

 Female

-

-

-

-

-

-

-

-

-

-

 Male

-

-

-

-

-

-

-

-

-

-

Year of diagnosis

 2007

-

-

-

-

-

-

-

-

-

-

 2008

-

-

-

-

-

-

-

-

-

-

 2009

-

-

-

-

-

-

-

-

-

-

 2010

-

-

-

-

-

-

-

-

-

-

Delay of treatment

  < 30 days

-

-

-

-

-

-

-

-

-

-

 (30–90] days

-

-

-

-

-

-

-

-

-

-

  > 90 days

-

-

-

-

-

-

-

-

-

-

Angiographic type of lesion

 Classic

-

-

-

-

-

-

-

-

-

-

 Predominantly classic

-

-

-

-

-

-

-

-

-

-

 Minimally classic

-

-

-

-

-

-

-

-

-

-

 Occult

-

-

-

-

-

-

-

-

-

-

 Others

-

-

-

-

-

-

-

-

-

-

Status of the fellow eye

 Initial/intermediate AMD

-

-

-

-

-

-

-

-

-

-

 Neovascular

-

-

-

-

-

-

-

-

-

-

Atrophic

-

-

-

-

-

-

-

-

-

-

 Disciform scar

-

-

-

-

-

-

-

-

-

-

 Others

-

-

-

-

-

-

-

-

-

-

Status of the lens

 Cataract

-

-

-

-

-

-

-

-

-

-

 Pseudophakia

-

-

-

-

-

-

-

-

-

-

 Transparent

-

-

-

-

-

-

-

-

-

-

BCVA

153

0.6119

0.3314

1.1298

0.1164

153

0.313

0.1742

0.5623

0.0001

CMT change

151

1.234

0.5158

2.9522

0.6367

151

0.5479

0.2503

1.1994

0.1323

OCT assessment

 SRF

43 (29.25)

0.9004

0.4568

1.9927

0.9004

24 (17.02)

1.0262

0.421

2.5014

0.9547

 Thickening

9 (6.12)

0.4934

0.1414

2.5674

0.4934

4 (2.84)

-

-

-

0.9891

 Both

9 (6.12)

0.2342

0.5657

10.2697

0.2342

9 (6.38)

1.516

0.3851

5.9677

0.5518

 None

86 (58.5)

1

-

-

-

104 (73.76)

1

-

-

-

Macular associated lesions

 Bleeding >50%

1 (0.9)

-

-

-

0.9944

1 (0.88)

-

-

-

0.9944

 PED

16 (14.41)

0.7143

0.2001

2.5495

0.6042

15 (13.16)

0.4667

0.1135

1.9195

0.2909

 RPE tear

3 (2.7)

-

-

-

0.9907

2 (1.75)

-

-

-

0.9924

 Initial minimal atrophy

20 (18.02)

2.1429

0.5856

7.8414

0.2495

26 (22.81)

5.3667

1.1472

25.105

0.0328

 Initial minimal fibrosis

47 (42.34)

0.1931

0.0662

0.5632

0.0026

52 (45.61)

0.1273

0.0374

0.4332

0.001

 RAP

0 (0)

-

-

-

-

0 (0)

-

-

-

-

 PV

0 (0)

-

-

-

-

1 (0.88)

-

-

-

0.9946

 Others

24 (21.62)

1

-

-

-

17 (14.91)

1

-

-

-

Total time of treatment

-

-

-

-

-

-

-

-

-

-

Number of injections

153

1.1762

0.9157

1.5107

0.2038

150

1.0851

0.8399

1.4021

0.5319

Number of visits

146

1.1098

0.9481

1.2991

0.1949

146

0.9166

0.7719

1.0885

0.3207

 

3 years

4 years

n (%)

OR

CI 95%

p-value

n (%)

OR

CI 95%

p-value

Age

-

-

-

-

-

-

-

-

-

-

Sex

 Female

-

-

-

-

-

-

-

-

-

-

 Male

-

-

-

-

-

-

-

-

-

-

Year of diagnosis

 2007

-

-

-

-

-

-

-

-

-

-

 2008

-

-

-

-

-

-

-

-

-

-

 2009

-

-

-

-

-

-

-

-

-

-

 2010

-

-

-

-

-

-

-

-

-

-

Delay of treatment

  < 30 days

-

-

-

-

-

-

-

-

-

-

 (30–90] days

-

-

-

-

-

-

-

-

-

-

  > 90 days

-

-

-

-

-

-

-

-

-

-

Angiographic type of lesion

 Classic

-

-

-

-

-

-

-

-

-

-

 Predominantly classic

-

-

-

-

-

-

-

-

-

-

 Minimally classic

-

-

-

-

-

-

-

-

-

-

 Occult

-

-

-

-

-

-

-

-

-

-

 Others

-

-

-

-

-

-

-

-

-

-

Status of the fellow eye

 Initial/intermediate AMD

-

-

-

-

-

30 (20.83)

1

-

-

-

 Neovascular

-

-

-

-

-

20 (13.89)

0.6667

0.212

2.0963

0.4879

 Atrophic

-

-

-

-

-

46 (31.94)

0.84

0.3343

2.1105

0.7107

 Disciform scar

-

-

-

-

-

35 (24.31)

1.0588

0.3992

2.8085

0.9086

 Others

-

-

-

-

-

13 (9.03)

0.4444

0.112

1.7634

0.2488

Status of the lens

          

 Cataract

-

-

-

-

-

-

-

-

-

-

 Pseudophakia

-

-

-

-

-

-

-

-

-

-

 Transparent

-

-

-

-

-

-

-

-

-

-

BCVA

153

0.2781

0.1539

0.5026

<0.0001

153

0.3332

0.1982

0.56

<0.0001

CMT change

151

0.4459

0.2122

0.937

0.003

151

0.4485

0.226

0.8901

0.0219

OCT assessment

 SRF

15 (15)

1.1722

0.3878

3.543

0.7784

5 (10)

2.8

0.4205

18.644

0.2871

 Thickening

4 (4)

0.3419

0.0341

3.4296

0.3616

0 (0)

-

-

-

-

 Both

2 (2)

-

-

-

0.988

2 (4)

-

-

-

-

 None

79 (79)

1

-

-

-

43 (86)

1

-

-

-

Macular associated lesions

 Bleeding >50%

0 (0)

-

-

-

-

0 (0)

-

-

-

-

 PED

8 (8.89)

0.5

0.065

3.8453

0.5054

1 (2.13)

-

-

-

0.9947

 RPE tear

3 (3.33)

-

-

-

0.9902

1 (2.13)

-

-

-

0.9943

 Initial minimal atrophy

26 (28.89)

6.3

1.2752

31.1244

0.0239

12 (25.53)

6

0.3901

92.277

0.1988

 Initial minimal fibrosis

43 (47.78)

0.3971

0.0919

1.7149

0.2159

30 (63.83)

0.4

0.0301

5.3073

0.4873

 RAP

0 (0)

-

-

-

-

0 (0)

-

-

-

-

 PV

0 (0)

-

-

-

-

0 (0)

-

-

-

-

 Others

10 (11.11)

1

-

-

-

3 (6.38)

1

-

-

-

Total time of treatment

-

-

-

-

-

153

0.9844

0.9557

1.014

0.2991

Number of injections

114

1.4048

1.081

1.8254

0.011

55

1.3943

1.01

1.9249

0.0434

Number of visits

114

0.9166

0.7719

1.0885

0.3207

58

1.1477

0.9012

1.4617

0.2642

  1. A total of 153 patients were included in the final univariate analysis for presence of geographic atrophy vs. fibrotic scar. This table shows all the variables evaluated in each visit during the 4 years of follow-up. OR: odds ratio, CI: confidence interval, AMD: age-related macular degeneration, BCVA: best corrected visual acuity, CMT: central macular thickness, SRF: subretinal fluid, PED: pigment epithelium detachment, RPE: retinal pigment epithelium, RAP: retinal angiomatous proliferation, PV: polypoidal vasculopathy. Statistically significant results appear in italic
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BMC Ophthalmology

ISSN: 1471-2415

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