Fig. 4
From: Cyclic stretch induced-retinal pigment epithelial cell apoptosis and cytokine changes
Western blotting analysis of apoptosis regulatory protein expression. a Coloured bands of Bcl2, Bax, and p53. b, c Expression levels of Bax, Bcl2 and p53. At 8 h, the Bcl2 and p53 expressions were significantly up-regulated (p < 0.01); the changes in Bax expression (p = 0.067) and the Bax/Bcl2 ratio (p = 0.957) were not statistically significant compared with the control group; however, thereafter, the Bax/Bcl2 ratio gradually increased with time. The expression of the p53 gene was significantly up-regulated at 14 h (p < 0.01). After stretch withdrawal, the Bax/Bcl2 ratio at R6h was significantly lower than that in another group where the stretch was not withdrawn (20 h) (p < 0.01), and the p53 expression was also significantly lower than in the stretch group (20 h) (p < 0.01)