Association of Interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis

Li, Junhua; Feng, Yifan; Sung, Mi Sun; Lee, Tae Hee; Park, Sang Woo

doi:10.1186/s12886-017-0616-y

BMC Ophthalmology

Table 1 Characteristics of the studies included in the meta-analysis

From: Association of Interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis

Authors/Year	Country	Ethnicity	Genotyping method	Type of POAG^a	Subjects (n)		MAF (%)		Genotypes for Cases			Genotypes for Controls			Test for HWE
Authors/Year	Country	Ethnicity	Genotyping method	Type of POAG^a	Cases	Controls	Cases	Controls	CC	CT	TT	CC	TC	TT	X²	P
IL-1β rs16944
Lin et al./2003 [13]	Taiwan	Asian	PCR-SSP	All	58	105	43.1	49.5	18	30	10	28	50	27	0.24	0.63
How et al./2007 [9]	Singapore	Asian	PCR-DS	All HTG non-HTG	194 100 94	79	46.4 42.0 51.1	43.0	56 35 21	96 46 50	42 19 23	24	42	13	0.56	0.45
Wang et al./2007 [10]	Taiwan	Asian	PCR-RFLP	non-HTG	231	245	46.3	49.6	70	108	53	61	125	59	0.10	0.75
Markiewicz et al./2013 [7]	Poland	Caucasian	PCR-RFLP	All	255	256	39.4	30.6	93	123	39	118	119	19	2.22	0.14
Mookherjee et al./2010 [8]	India	Asian	PCR-RFLP	All HTG non-HTG	315 116 199	301	56.2 55.6 56.6	60.6	61 23 38	154 57 97	100 36 64	47	143	111	0.007	0.93
IL-1α rs1800587
How et al./2007 [9]	Singapore	Asian	PCR-DS	All HTG non-HTG	189 100 89	79	8.7 7.0 10.7	10.8	158 87 71	29 12 17	2 1 1	64	13	2	1.62	0.20
Wang et al./2007 [11]	Taiwan	Asian	PCR-RFLP	non-HTG	162	167	14.5	13.2	118	41	3	125	40	2	0.37	0.54
Wang et al./2006 [12]	Taiwan	Asian	PCR-RFLP	HTG	156	167	21.2	13.2	98	50	8	125	40	2	0.37	0.54
Mookherjee et al./2010 [8]	India	Asian	PCR-RFLP	All HTG non-HTG	315 116 199	301	28.9 34.5 25.6	32.2	160 50 110	128 52 76	27 14 13	138	132	31	0.005	0.95
IL-1β rs1143634
How et al./2007 [9]	Singapore	Asian	PCR-DS	All HTG non-HTG	194 100 94	79	1.8 3.0 0.5	1.2	187 94 93	7 6 1	0 0 0	77	2	0	0.01	0.91
Lin et al./2003 [13]	Taiwan	Asian	PCR-SSP	All	58	105	6.0	1.5	51	7	0	102	3	0	0.02	0.88
Wang et al./2007 [10]	Taiwan	Asian	PCR-RFLP	non-HTG	231	245	3.9	4.1	214	16	1	226	18	1	0.93	0.33
Mookherjee et al./2010 [8]	India	Asian	PCR-RFLP	All HTG non-HTG	315 116 199	301	14.6 16.8 13.3	11.5	230 80 150	78 33 45	7 3 4	236	61	4	0.0007	0.98

HTG high tension glaucoma, PCR polymerase chain reaction, DS direct sequencing, RFLP restriction fragment length polymorphism, SSP sequence-specific primer, MAF minor allele frequency
^aPOAG patients were subdivided to two groups: HTG (IOP > 21 mmHg) and non-HTG (IOP < 21 mmHg, with or without a strict diurnal testing)

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