Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye

Table 12 Correlations among cytokine levels at baseline in dry eye disease patients (all enrolled population)

	EGF	IFN-γ	IL-1α	IL-1β	IL-2	IL-6	IL-8	IL-17	IP-10	TNF-α
IFN-γ	0.30400 < 0.0001	–
IL-1α	0.23297 0.0027	0.32068 < 0.0001	–
IL-1β	0.51640 < 0.0001	0.41754 < 0.0001	0.66743 < 0.0001	–
IL-2	0.25249 0.0011	0.49808 < 0.0001	0.16664 0.0329	0.42179 < 0.0001	–
IL-6	0.76740 < 0.0001	0.35501 < 0.0001	0.33220 < 0.0001	0.57020 < 0.0001	0.23707 0.0022	–
IL-8	0.75670 < 0.0001	0.28040 0.0003	0.24529 0.0015	0.40306 < 0.0001	0.27415 0.0004	0.80562 < 0.0001	–
IL-17	0.31044 < 0.0001	0.45138 < 0.0001	0.27422 0.0004	0.30745 < 0.0001	0.17318 0.0266	0.38157 < 0.0001	0.26181 0.0007	–
IP-10	0.58512 < 0.0001	0.15471 0.0479	0.33144 < 0.0001	0.38843 < 0.0001	0.06706 0.3936	0.64034 < 0.0001	0.69808 < 0.0001	0.21564 0.0056	–
TNF-α	0.37737 < 0.0001	0.58537 < 0.0001	0.27896 0.0003	0.44958 < 0.0001	0.56420 < 0.0001	0.49181 < 0.0001	0.40005 < 0.0001	0.36543 < 0.0001	0.26294 0.0007	–

EGF Epidermal growth factor, IFN-γ Interferon gamma, IL Interleukin, IP-10 Interferon-gamma-inducible protein 10, TNF-α Tumor necrosis factor alpha
Correlation coefficients and P-values (H₀:Rho = 0) are presented within each cell

ISSN: 1471-2415