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Table 6 Survey of symptoms: dry eye disease versus control populations (all enrolled population)

From: Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye

Time Period

Category

Statistic

All cases (n = 217)

All controls (n = 67)

P-value

Past Week

     
 

Stinging/Burning

    
 

 Experienced, n (%)

None of the time

50 (23.04)

58 (86.57)

<0.0001

  

Some of the time

103 (47.47)

8 (11.94)

 
  

Half of the time

31 (14.29)

0 (0.00)

 
  

Most of the time

21 (9.68)

1 (1.49)

 
  

All of the time

8 (3.69)

0 (0.00)

 
  

Missing

4 (1.84)

0 (0.00)

 
 

 Bothered

N

209

63

<0.0001

  

Mean (SD)

1.49 (1.097)

0.19 (0.503)

 
 

Dryness

    
 

 Experienced, n (%)

None of the time

12 (5.53)

53 (79.10)

<0.0001

  

Some of the time

73 (33.64)

10 (14.93)

 
  

Half of the time

43 (19.82)

3 (4.48)

 
  

Most of the time

58 (26.73)

0 (0.00)

 
  

All of the time

28 (12.90)

0 (0.00)

 
  

Missing

3 (1.38)

1 (1.49)

 
 

 Bothered

N

210

63

<0.0001

  

Mean (SD)

2.17 (1.143)

0.24 (0.560)

 
 

Foreign Body Sensation

    
 

 Experienced, n (%)

None of the time

31 (14.29)

55 (82.09)

<0.0001

  

Some of the time

117 (53.92)

11 (16.42)

 
  

Half of the time

33 (15.21)

0 (0.00)

 
  

Most of the time

20 (9.22)

1 (1.49)

 
  

All of the time

13 (5.99)

0 (0.00)

 
  

Missing

3 (1.38)

0 (0.00)

 
 

 Bothered

N

209

63

<0.0001

  

Mean (SD)

1.66 (1.170)

0.25 (0.671)

 
 

Itching

    
 

 Experienced, n (%)

None of the time

50 (23.04)

47 (70.15)

<0.0001

  

Some of the time

88 (40.55)

18 (26.87)

 
  

Half of the time

36 (16.59)

1 (1.49)

 
  

Most of the time

32 (14.75)

1 (1.49)

 
  

All of the time

8 (3.69)

0 (0.00)

 
  

Missing

3 (1.38)

0 (0.00)

 
 

 Bothered

N

205

63

<0.0001

  

Mean (SD)

1.43 (1.168)

0.37 (0.679)

 
 

Light Sensitivity

    
 

 Experienced, n (%)

None of the time

39 (17.97)

56 (83.58)

<0.0001

  

Some of the time

86 (39.63)

11 (16.42)

 
  

Half of the time

35 (16.13)

0 (0.00)

 
  

Most of the time

33 (15.21)

0 (0.00)

 
  

All of the time

21 (9.68)

0 (0.00)

 
  

Missing

3 (1.38)

0 (0.00)

 
 

 Bothered

N

207

63

<0.0001

  

Mean (SD)

1.74 (1.265)

0.21 (0.513)

 
 

Painful/Sore

    
 

 Experienced, n (%)

None of the time

98 (45.16)

61 (91.04)

<0.0001

  

Some of the time

77 (35.48)

6 (8.96)

 
  

Half of the time

22 (10.14)

0 (0.00)

 
  

Most of the time

14 (6.45)

0 (0.00)

 
  

All of the time

2 (0.92)

0 (0.00)

 
  

Missing

4 (1.84)

0 (0.00)

 
 

 Bothered

N

207

62

<0.0001

  

Mean (SD)

1.01 (1.106)

0.11 (0.409)

 
 

Intermittent Blurred Vision

    
 

 Experienced, n (%)

None of the time

37 (17.05)

57 (85.07)

<0.0001

  

Some of the time

104 (47.93)

8 (11.94)

 
  

Half of the time

44 (20.28)

2 (2.99)

 
  

Most of the time

18 (8.29)

0 (0.00)

 
  

All of the time

10 (4.61)

0 (0.00)

 
  

Missing

4 (1.84)

0 (0.00)

 
 

 Bothered

N

206

61

<0.0001

  

Mean (SD)

1.67 (1.175)

0.16 (0.522)

 
 

Tired/Fatigued Eyes

    
 

 Experienced, n (%)

None of the time

23 (10.60)

43 (64.18)

<0.0001

  

Some of the time

108 (49.77)

21 (31.34)

 
  

Half of the time

32 (14.75)

2 (2.99)

 
  

Most of the time

39 (17.97)

0 (0.00)

 
  

All of the time

11 (5.07)

1 (1.49)

 
  

Missing

4 (1.84)

0 (0.00)

 
 

 Bothered

N

208

62

<0.0001

  

Mean (SD)

1.75 (1.109)

0.37 (0.752)

 
 

Frequent Blinking

    
 

 Experienced, n (%)

None of the time

52 (23.96)

60 (89.55)

<0.0001

  

Some of the time

72 (33.18)

6 (8.96)

 
  

Half of the time

40 (18.43)

1 (1.49)

 
  

Most of the time

31 (14.29)

0 (0.00)

 
  

All of the time

18 (8.29)

0 (0.00)

 
  

Missing

4 (1.84)

0 (0.00)

 
 

 Bothered

N

207

61

<0.0001

  

Mean (SD)

1.34 (1.188)

0.10 (0.300)

 
 

Other

    
 

 Experienced, n (%)

None of the time

55 (25.35)

40 (59.70)

<0.0001

  

Some of the time

2 (0.92)

0 (0.00)

 
  

Half of the time

6 (2.76)

0 (0.00)

 
  

Most of the time

6 (2.76)

0 (0.00)

 
  

All of the time

2 (0.92)

0 (0.00)

 
  

Missing

146 (67.28)

27(40.30)

 
 

 Bothered

N

70

39

0.0015

  

Mean (SD)

0.69 (1.314)

0.00 (0.000)

 
  1. “Bothered” evaluated by the patient using a 5-point scale where 0 = not at all and 4 = extremely