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Table 8 Summary of reported treatments for dry eye symptoms: comparison of dry eye disease and control populations

From: Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye

Time Period

Category

Statistic

All cases (n = 217)

All controls (n = 67)

P-value

Past month

Used artificial tears

N

160

49

 

Mean (SD)

16.02 (12.722)

2.27 (6.623)

<0.0001

Min–Max

0.0–62.0

0.0–30.0

 

Used eye ointments

N

139

45

 

Mean (SD)

2.13 (7.087)

0 (0)

0.0457

Min–Max

0.0–30.0

0.0–0.0

 

Past 3 months

Own money (dollars) spent on treatments for DE (dollars)

N

162

47

 

Mean (SD)

33.56 (57.832)

2.87 (7.854)

0.0004

Med

15

0

 

Min - Max

0–400

0–30

 

DED symptoms main cause to use medication? n (%)

Eye Drops

   

 Antibiotic drops

3 (1.38)

1 (1.49)

0.5044

 Non-prescription

46 (21.20)

6 (8.96)

 

 Prescription

5 (2.30)

0 (0.00)

 

 Steroids

0(0.00)

0 (0.00)

 

Pills

   

 Analgesic/anti-inflammatory (OTC)

4 (1.84)

0 (0.00)

<0.0001

 Analgesics/anti-inflammatory (Rx)

9 (4.15)

0 (0.00)

 

 Antidepressants

0 (0.00)

1 (1.49)

 

 Antibiotics

0 (0.00)

0 (0.00)

 

 Anti-allergy (OTC)

12 (5.53)

3 (4.48)

 

 Anti-allergy (Rx)

0 (0.00)

0 (0.00)

 

 Other

4 (1.84)

0 (0.00)

 

Special procedures, n (%)

 

Punctal occlusion or plugs, n (%)

Have not had

134 (61.75)

42 (62.69)

0.2319

Less than 1 yr. ago

3 (1.38)

0 (0.00)

 

1–2 years ago

3 (1.38)

0 (0.00)

 

3 or more yrs. ago

8 (3.69)

0 (0.00)

 

Eye lid surgery, n (%)

Have not had

138 (63.59)

41 (61.19)

0.6136

Less than 1 yr. ago

0 (0.00)

0 (0.00)

 

1–2 yrs. ago

1 (0.46)

0 (0.00)

 

3 or more yrs. ago

8 (3.69)

1 (1.49)

 

Overall satisfaction with treatment, n (%)

Currently not using treatments

37 (17.05)

37 (55.22)

<0.0001

Overall dissatisfied

0 (0.00)

0 (0.00)

 

Very dissatisfied

11 (5.07)

0 (0.00)

 

Somewhat dissatisfied

28 (12.90)

1 (1.49)

 

Neutral

32 (14.75)

5 (7.46)

 

Somewhat satisfied

36 (16.59)

1 (1.49)

 

Very satisfied

19 (8.76)

4 (5.97)

 

Missing result

54 (24.88)

19 (28.36)

 
  1. OTC Over-the-counter, Rx prescription
  2. For artificial tear and eye ointment use, the number of days used in the past 1 month is presented
  3. P-values for continuous endpoints taken from two sample t-test. P-values from categorical endpoints taken from chi-squared test