| Patient 1 | Patient 2 | Patient 3 |
---|---|---|---|
Primary endpoint (month 2) | |||
 VH (reduction) score | 0.5+ | 0.5+ (−1) | 0 (−1.5) |
Secondary endpoint (month 6) | |||
 BCVA in ETDRS-letters (gain) | 82 (+17) | 79 (+24) | 69 (+11) |
 CRT in μm (reduction) | 265 (−186) | 319 (−1) | 267 (−83) |
 Concomitant medication (change) | CSA 2.1 mg/kg bodyweight daily, (+Decortin 0.1 mg/kg bodyweight once daily) | Decortin 0.2 mg/kg bodyweight once daily | MTX 6.25 mg/m2/once weekly (−MTX 2.5 mg weekly; − Decortin 0.03 mg/kg bodyweight once daily) |
Safety endpoints (month 6) | |||
 IOP | 19 | 11 | 13 |
 Number of IOP lowering medications during study course (topical or oral) | 3 (topical) | 2 (topical) | 5 (4 topical, 1 oral) |
 Number of IOP lowering surgeries during study course | 0 | 0 | 0 |
 CDR (increase) | 0.2 | 0.2 | 0.2 (+0.1) |
 Cataract status | clear | clear | Subcapsular cataract grade 2+ (no progression) |