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Table 2 Quantitative PCR confirmation of retinal gene expression 4 h postinfection with B. cereus ATCC14579

From: TLR4 modulates inflammatory gene targets in the retina during Bacillus cereus endophthalmitis

Gene symbol C57BL/6 J Fold change TLR4−/− Fold change
CCL2 515 ± 742 NC
IL-6 118 ± 157 NC
CXCL2 56 ± 37 NC
CCL3 47 ± 31 NC
PTX3 32 ± 36 NC
CXCL1 30 ± 23 NC
LIF 29 ± 33 NC
CXCL10 27 ± 16 NC
ICAM1 16 ± 10 NC
SOCS3 12 ± 7 NC
PTGS2 6 ± 4 NC
  1. C57BL/6 J fold change values are relative to uninfected C57BL/6 J mice eyes, and TLR4−/− fold change values are relative to uninfected TLR4−/− mice eyes. For each gene, qPCR was performed in triplicate on two independently prepared RNA samples. Significant differences between infected and uninfected eyes were assessed using a Paired T-test, and statistical significance was defined as p < 0.05
  2. NC no change