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Table 2 Quantitative PCR confirmation of retinal gene expression 4 h postinfection with B. cereus ATCC14579

From: TLR4 modulates inflammatory gene targets in the retina during Bacillus cereus endophthalmitis

Gene symbol

C57BL/6 J Fold change

TLR4−/− Fold change

CCL2

515 ± 742

NC

IL-6

118 ± 157

NC

CXCL2

56 ± 37

NC

CCL3

47 ± 31

NC

PTX3

32 ± 36

NC

CXCL1

30 ± 23

NC

LIF

29 ± 33

NC

CXCL10

27 ± 16

NC

ICAM1

16 ± 10

NC

SOCS3

12 ± 7

NC

PTGS2

6 ± 4

NC

  1. C57BL/6 J fold change values are relative to uninfected C57BL/6 J mice eyes, and TLR4−/− fold change values are relative to uninfected TLR4−/− mice eyes. For each gene, qPCR was performed in triplicate on two independently prepared RNA samples. Significant differences between infected and uninfected eyes were assessed using a Paired T-test, and statistical significance was defined as p < 0.05
  2. NC no change
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BMC Ophthalmology

ISSN: 1471-2415

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