Fig. 1
From: Characterization, treatment and prognosis of retinoblastoma with central nervous system metastasis
Representative MRI results of retinoblastoma patients with CNS metastasis. (a1–3) Head contrast-enhanced MRI: visible diffuse enhancement of the intracranial pial from sagittal, axial, and coronal imaging, respectively, cervical spinal cord membrane also show enhancement. (b1–3) Head and orbital contrast-enhanced MRI: sagittal image shows thickened meninges of the anterior, middle and posterior cranial fossa, brain stem surface, and the cerebellum (b1); and orbital MRI images show enhanced signaling of nodules, possibly spreading via the cerebrospinal fluid (b2–3). (c1–4) Head MRI: signs of optical nerve, optic chiasma, and supra sella cistern involvement, respectively (c1–3); visible mass formed in the supra sella cistern, and enhanced signal of the cerebral falx (c4). MRI: magnetic resonance imaging; CNS: central nervous system