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Table 1 Summary of the characteristics of the included studies

From: A meta-analysis of the effect of a dexamethasone intravitreal implant versus intravitreal anti-vascular endothelial growth factor treatment for diabetic macular edema

Study

Place

Conditions

Participants numbers

Interventions details

Total number of treatments

Age (years)

Female sex, no. (%)

BCVA at baseline

CST/CMT (μm) at baseline

Follow-up duration (months)

Gillies et al. 2014 < The BEVORDEX Study> [23]

Australia

DR

DEX: 46

IVB: 42

DEX: 0.7 mg every 16 weeks + PRN

IVB: 0.5 mg every 4 weeks + PRN

DEX: 2.7

IVB: 8.6

DEX: 61.4 ± 9.0

IVB: 62.2 ± 10.5

(P = 0.71)

DEX: 16 (35%)

IVB: 16 (38%)

(P = 0.83)

DEX: 55.5 ± 12.5

IVB: 56.3 ± 11.9

(P = 0.75)

DEX: 474.3 ± 95.9

IVB: 503 ± 140.9

(P = 0.38)

12

Allergan 2015 [27]

Multiple countries: Belgium, Denmark, France, Germany, Israel, Italy, Netherlands, Portugal, South Africa, Spain, United Kingdom, United States

DR

DEX: 181

IVR: 182

DEX: 0.7 mg on Day 1, Month 5, and Month 10

IVR: 0.5 mg into the study eye on Day 1. Patients may receive additional injections on a monthly basis, as needed, for disease progression

NA

NA

DEX: 69 (38%)

IVR: 66 (36%)

DEX: 60.2 ± 9.74

IVR: 60.4 ± 9.34

DEX: 465.1 ± 136.09

IVR: 471.2 ± 139.51

12

Shah et al. 2016 [24]

Indiana, United States

DR

DEX: 27

IVB: 23

DEX: 0.7 mg given every 3 months over 6 month period with a maximum of 3 injections

IVB: 1.25 mg given monthly during a 6 month period

DEX: 2.7 ± 0.5

IVB: 7.0 ± 0.2

(P < 0.001)

DEX: 65 ± 11

IVB: 61 ± 9

(P = 0.209)

DEX: 15 (56%)

IVB: 10 (44%)

(P = 0.571)

DEX: 59 ± 12

IVB: 59 ± 13

(P = 0.770)

DEX: 458 ± 100

IVB: 485 ± 122

(P = 0.508)

7

Gallemore et al. 2017 [26]

California, United States

DR

DEX: 10

IVB: 10

DEX: Ozurdex, 0.7 mg given at initial visit and at month 4 (visit 5)

IVB: 1.25 mg given at initial visit and Q1 month for a total of 5 treatments

NA

DEX: 63.9 ± 1.8

IVB: 61.2 ± 2.9

DEX: 5 (50%)

IVB: 3 (30%)

DEX: 67.8 ± 3.8

IVB: 71.9 ± 2.9

DEX: 385.9 ± 43.0

IVB: 341.5 ± 11.3

6

  1. NA not available, PRN pro re nata