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Fig. 2 | BMC Ophthalmology

Fig. 2

From: Intermittent high glucose-induced oxidative stress modulates retinal pigmented epithelial cell autophagy and promotes cell survival via increased HMGB1

Fig. 2

Intermittent high glucose induces RPE autophagy and alters the expression pattern of autophagic markers. a: Transmission electron microscopy examination revealed that intermittent high glucose lead to an increase in the number of double-membrane vacuoles, which was a typical of autophagosomes. b-d: Western blot results showed that intermittent high glucose lead to a significant increase in conservation of LC3-II. Intermittent high glucose resulted in a marked decrease in p62 protein expression. (*p < 0.05 vs. control, #p < 0.05 vs. HG)

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