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Fig. 3 | BMC Ophthalmology

Fig. 3

From: Intermittent high glucose-induced oxidative stress modulates retinal pigmented epithelial cell autophagy and promotes cell survival via increased HMGB1

Fig. 3

Effect of lysosomal inhibitors and antioxidant on intermittent high glucose-induced RPE autophagy and proliferative activity. a, b, d, e: Intermittent high glucose treatment in the presence of either NH4Cl or NAC decreased the level of LC3-II/LC3-I in ARPE-19 cells. c, f: Intermittent high glucose treatment in the presence of either NH4Cl or NAC resulted in a marked increase in p62 protein expression. g-h: Compared with the HG-Int group, intermittent high glucose treatment in the presence of either NH4Cl or NAC resulted in an obvious reduction in proliferative activity. (*p < 0.05 vs. control, #p < 0.05 vs. HG)

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