Association of Genes implicated in primary angle-closure Glaucoma and the ocular biometric parameters of anterior chamber depth and axial length in a northern Chinese population

Table 2 Association results of target SNPs with PACG after adjustment for age and sex

GENE	SNP	CHR	BP	Minor allele	Genotype (AA/AB/BB)^a		MAF		HWE-p		OR (95% CI)	P
GENE	SNP	CHR	BP	Minor allele	Case	Control	Case	Control	Case	Control	OR (95% CI)	P
ZNRF3	rs7290117	22	29,450,856	T	427/72/1	632/84/4	0.074	0.064	0.5056	0.524	1.306(0.9007~ 1.894)	0.159
ZNRF3	rs2179129	22	29,450,923	G	179/238/83	236/347/137	0.404	0.431	0.7813	0.6487	0.9095 (0.7571~ 1.092)	0.3105
ZNRF3	rs4823006	22	29,451,671	G	130/252/118	200/381/139	0.488	0.458	0.9287	0.08442	1.166 (0.9671~ 1.407)	0.1073
ZNRF3	rs3178915	22	29,453,027	A	168/243/88	252/358/108	0.419	0.400	1	0.3128	1.085 (0.8992~ 1.309)	0.3954
HGF	rs5745718	7	81,347,548	T	366/124/10	537/172/11	0.144	0.134	1	0.6314	0.9475 (0.7256~ 1.237)	0.6924
HGF	rs12536657	7	81,350,208	A	363/126/10	534/174/11	0.146	0.136	1	0.5287	0.9514 (0.7292~ 1.241)	0.7132
HGF	rs12540393	7	81,364,187	C	342/143/14	513/191/16	0.171	0.155	1	0.8865	0.9266 (0.7216~ 1.19)	0.5503
HGF	rs17427817	7	81,364,435	C	342/144/14	512/192/16	0.172	0.155	0.8764	0.7774	0.9249 (0.7203~ 1.188)	0.5405
HGF	rs3735520	7	81,400,939	A	139/258/103	227/349/144	0.464	0.442	0.4199	0.6505	1.191 (0.9897~ 1.433)	0.06434
MFRP	rs2510143	11	119,216,231	A	372/119/9	515/186/19	0.137	0.156	1	0.6699	0.8559 (0.6603~ 1.109)	0.2396
MFRP	rs36015759	11	119,216,279	A	289/178/33	425/252/43	0.244	0.235	0.4665	0.4694	1.085 (0.8794~ 1.338)	0.4478
MFRP	rs3814762	11	119,216,504	T	328/151/21	479/211/29	0.193	0.187	0.4746	0.3285	0.946 (0.7259~ 1.189)	0.6337

^aA represents the wild-type allele, B represents the minor allele; CHR chromosome, BP base pair position, MAF minor allele frequency, HWE-p the p-value of Hardy-Weinburg equilibrium, OR odds ratio, CI confidence interval
P-value, OR, and CI were calculated with a logistic regression model by adjusting for age and sex

ISSN: 1471-2415