Fig. 4

Infiltration of ED-1(+) cells and Iba-1(+) cells both were detected in the ONs post-AION. a, d At sham group, occasional ED-1(+) cells and distributed Iba-1(+) cells were found in the peripapillary choroid(white arrows) as well as in the anterior ON surrounding a blood vessel(red arrows); b, e At 3 days post-AION, scattered ED-1(+) cells had a moderate increase especially in the choroid and next to the blood vessels; Iba-1(+) cells had a significat gatheration on the anterior ON; c, f At 14 days post-AION, ED-1(+) as well as Iba-1(+) cells widely distributed on ON, and both reached the peak (67.5 ± 9.57 cells/HPF and 77.5 ± 12.58 cells/HPF, respectively), **P < 0.01 compared with the sham group (N = 6 in each group)