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Table 1 The General Characteristics of All Studies Included in our Meta-Analysis

From: Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis

Refs

Year

Country

Ethnicity

Case/Control

Mean age of AMD

Mean age of control

Typing teaching

Study design

Yate et al. [54]

2007

UK

Caucasian

603/350

79.4 ± 7.2

75.3 ± 7.8

SNaPshot

Sex-,age-,ethnic-,matched

Yate et al. [54]

2007

Scotland

Caucasian

244/351

77.8 ± 9.2

78.0 ± 8.5

TaqMan

Sex-,age-,ethnic-,matched

Maller et al. [41]

2007

America

Caucasian

1238/934

NA

NA

MALDI-TOF MS

Age-,ethnic-, matched

Edwards et al. [31]

2008

America

Caucasian

444/300

NA

NA

Illumina GoldenGate

Age-,ethnic-, matched

Spencer et al. [50]

2008

America

Caucasian

286/701

76.5 ± 7.7

66.9 ± 8.3

TaqMan

Sex-,age-,ethnic-,matched

Scholl et al. [4]

2009

German

Caucasian

99/612

71.8 ± 7.4

76.2 ± 5.3

MALDI-TOF MS

Sex-,age-,ethnic-,matched

Francis et al. [32]

2009

America

Caucasian

211/187

79

74

Sequencing

Age-,ethnic-, matched

Park et al. [44]

2009

America

Caucasian

898/599

80.6 ± 5.0

77.6 ± 4.3

Illumina GoldenGate

Sex-,age-,ethnic-,matched

Despriet et al. [30]

2009

Netherlands

Caucasian

268/173

78.7 ± 7.7

74.1 ± 6.3

TaqMan

Sex-,age-,ethnic-,matched

Bergeron et al. [22]

2009

America

Caucasian

421/215

64.8

66.5

TaqMan

Sex-,age-,ethnic-,matched

Reynolds et al. [47]

2009

America

Caucasian

120/60

82.0 ± 6.9

79.0 ± 4.4

MALDI-TOF MS

Sex-,age-,ethnic-,matched

Pei et al.[45]

2009

China

East Asian

123/130

70.6 ± 8.2

69.2 ± 10.1

MALDI-TOF MS

Sex-,age-,ethnic-, matched

Cui et al. [29]

2010

China

East Asian

150/161

66.6 ± 8.4

65.7 ± 7.8

PCR-RFLP/ Sequencing

Sex-,age-,ethnic-, matched

Zerbib et al. [56]

2010

France

Caucasian

1080/406

79.0 ± 7.4

67.8 ± 7.7

TaqMan

Sex-,age-,ethnic-, matched

McKay et al. [43]

2010

Northern Ireland

Caucasian

437/436

77.6

74.9

SNaPshot

Sex-,age-,ethnic-, matched

Chen et al. [25]

2010

America

Caucasian

2157/1150

78.6

74.1

Illumina GoldenGate

Sex-,age-,ethnic-, matched

Kopplin et al. [37]

2010

America

Caucasian

377/161

NA

NA

Affymetrix GeneChip

Age-,ethnic-, matched

Liu et al. [39]

2010

China

East Asian

158/220

64.0 ± 6.6

63.0 ± 7.8

SNaPshot

Sex-,age-,ethnic-, matched

Yu et al. [55]

2011

America

Caucasian

1082/221

79.5 ± 5.5

77.0 ± 4.6

MALDI-TOF MS

Sex-,age-,ethnic-, matched

Chen et al. [26]

2011

America

Caucasian

1335/509

70.2 ± 5.1

67.0 ± 4.3

SNaPshot

Sex-,age-,ethnic-, matched

Hageman et al. [33]

2011

America

Caucasian

1132/822

76.5 ± 7.1

76.4 ± 7.3

NA

Sex-,age-,ethnic-, matched

Peter et al. [46]

2011

America

Caucasian

48/1260

NA

NA

TaqMan

Age-,ethnic-, matched

Yanagisawa et al. [53]

2011

Japan

East Asian

420/197

74.0 ± 7.5

72.0 ± 6.0

TaqMan

Sex-,age-,ethnic-, matched

Martinez et al. [42]

2012

Spain

Caucasian

259/191

NA

NA

SNaPshot

Age-,ethnic-, matched

Smailhodzic et al. [49]

2012

Netherlands

Caucasian

197/150

NA

NA

Sequencing

Sex-,age-,ethnic-, matched

Buentello et al. [23]

2012

Mexico

Caucasian

159/152

76.4 ± 8.1

73.5 ± 6.8

PCR-RFLP

Sex-,age-,ethnic-, matched

Tian et al. [51]

2012

China

East Asian

535/469

NA

NA

MALDI-TOF MS

Age-,ethnic-, matched

Losonczy et al. [40]

2012

Hungary

Caucasian

275/106

76.0 ± 7.3

79.1 ± 6.1

PCR-RFLP

Sex-,age-,ethnic-, matched

Cipriani et al. [27]

2012

UK

Caucasian

893/2199

78.6 ± 7.5

NA

Illumina BeadChip

Sex-,age-,ethnic-, matched

Jaouni et al. [36]

2012

Israel

Middle East

317/159

78.1 ± 7.6

70.8 ± 8.2

PCR-RFLP

Sex-,age-,ethnic-, matched

Wu et al. [52]

2013

China

East Asian

165/216

69.4 ± 10

64.5 ± 8.0

TaqMan

Sex-,age-,ethnic-, matched

Helgason et al. [35]

2013

Iceland

Caucasian

1107/2869

NA

NA

Illumina BeadChip

Age-,ethnic-, matched

Helgason et al. [35]

2013

America

Caucasian

1525/1288

NA

NA

Illumina BeadChip

Age-,ethnic-, matched

Contreras et al. [28]

2014

Mexico

Caucasian

273/201

76.0 ± 8.0

65.5 ± 9.8

TaqMan

Sex-,age-,ethnic-, matched

Caire et al. [24]

2014

Spain

Caucasian

154/141

75.4 ± 7.2

78.5 ± 7.2

SNaPshot

Sex-,age-,ethnic-, matched

Liu et al. [38]

2014

China

East Asian

200/275

75.3 ± 7.7

74.3 ± 7.6

TaqMan

Sex-,age-,ethnic-, matched

Hautamaki et al. [34]

2015

Finland

Caucasian

301/119

NA

NA

Sequencing

Age-,ethnic-, matched

Saksens et al. [48]

2016

Netherlands

Caucasian

571/900

76.6 ± 8.5

71.3 ± 6.7

KASP

Sex-,age-,ethnic-, matched

Bonyadi et al. [20, 21]

2017

Iran

Middle East

266/228

76.4 ± 7.6

72.7 ± 6.8

PCR-RFLP

Sex-,age-,ethnic-, matched

Habibi et al. [57]

2017

Tunisia

Middle East

145/207

73.1 ± 8.1

NA

PCR-SSP

Age-,ethnic-, matched