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Table 3 Main Results of Pooled ORs and Analysis of C3 gene polymorphism with advanced AMD in our Meta-Analysis

From: Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis

Subgroup

No. of studies

No. of patients

Allele model

Homozygote model

Heterozygote model

Dominant model

Recessive model

Cases

Control

OR(95% CI)

P

OR(95% CI)

P

OR(95% CI)

P

OR(95% CI)

P

OR(95% CI)

P

C3 rs2230199 (Associated allele vs. Reference allele: G vs. C)

Overall

36

34,805

29,499

1.49 (1.39,1.59)

< 0.001

2.33 (1.98,2.74)

< 0.001

1.53 (1.41,1.64)

< 0.001

1.62 (1.51,1.74)

< 0.001

1.99 (1.70,2.34)

< 0.001

Caucasian

28

31,372

26,130

1.48 (1.38,1.59)

< 0.001

2.20 (1.87,2.60)

< 0.001

1.55 (1.43,1.67)

< 0.001

1.63 (1.51,1.75)

< 0.001

1.88 (1.59,2.21)

< 0.001

East Asian

5

2122

2388

1.11 (0.56,2.20)

0.76

–

–

1.32 (0.91,1.93)

0.144

1.49 (1.04,2.15)

0.032

5.60 (1.57,19.9)

–

Middle East

3

1311

981

1.62 (1.33,1.97)

< 0.001

–

–

1.07 (0.66,1.73)

0.798

1.49 (0.95,2.34)

0.085

25.5 (3.35,194)

–

C3 rs1047286 (Associated allele vs. Reference allele: T vs. C)

Overall

13

16,232

16,222

1.45 (1.37,1.54)

< 0.001

2.06 (1.56,2.72)

< 0.001

1.72 (1.51,1.96)

< 0.001

1.76 (1.56,2.00)

< 0.001

1.71 (1.30,2.24)

< 0.001

Caucasian

10

14,688

14,548

1.45 (1.37,1.54)

< 0.001

2.06 (1.56,2.72)

< 0.001

1.72 (1.50,1.96)

< 0.001

1.76 (1.55,2.00)

< 0.001

1.71 (1.30,2.24)

< 0.001

East Asian

3

1544

1674

1.75 (0.49,6.29)

0.388

–

–

2.06 (0.38,11.3)

0.404

2.06 (0.38,11.3)

0.404

–

–

C3 rs2230205 (Associated allele vs. Reference allele: A vs. G)

Overall

5

3302

2732

0.99 (0.89,1.11)

0.903

1.04 (0.77,1.42)

0.780

1.00 (0.80,1.23)

0.967

1.00 (0.81,1.22)

0.992

1.06 (0.81,1.37)

0.687

Caucasian

1

880

598

0.90 (0.66,1.23)

0.507

0.45 (0.12,1.60)

0.215

0.98 (0.69,1.39)

0.902

0.93 (0.66,1.32)

0.699

0.45 (0.13,1.60)

0.217

East Asian

4

2422

2134

1.01 (0.89,1.14)

0.903

1.10 (0.80,1.51)

0.546

1.01 (0.77,1.32)

0.967

1.04 (0.80,1.33)

0.787

1.10 (0.84,1.43)

0.497

C3 rs2250656 (Associated allele vs. Reference allele: G vs. A)

Overall

5

3278

2632

0.90 (0.75,1.08)

0.257

0.76 (0.49,1.16)

0.207

0.78 (0.65,0.95)

0.014

0.78 (0.65,0.94)

0.010

0.83 (0.55,1.27)

0.391

Caucasian

1

874

512

0.82 (0.64,1.05)

0.117

0.77 (0.42,1.42)

0.407

0.76 (0.55,1.05)

0.097

0.76 (0.56,1.04)

0.085

0.87 (0.48,1.57)

0.642

East Asian

4

2404

2120

0.92 (0.73,1.16)

0.486

0.74 (0.41,1.37)

0.340

0.80 (0.63,1.02)

0.068

0.79 (0.63,1.00)

0.052

0.80 (0.44,1.45)

0.456

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BMC Ophthalmology

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