Table 1 Characteristics of the included studies
First author | Year | Country | Ethnicity | Female percentage (%) | HWE | Age | NOS | Method of DR ascertainment | Genotyping method | Cases (n) | Controls (n) | MAF (%) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | Cases | Controls | |||||||||||
Kamiuchi | 2002 | Japan | Asians | 52.0 | 56.8 | Yes | 64.3 ± 8.9 | 64.1 ± 9.1 | 7 | Ophthalmoscopy and fluorescein angiography | PCR-RFLP | 81 | 50 | 50.0 |
Liu | 2006 | China | Asians | PDR: 66.3 NPDR: 67.3 | 50.0 | Yes | PDR: 55.0 ± 12.4 NPDR: 63.7 ± 7.9 | 50.2 ± 10.6 | 7 | NA | DNA sequencing | 132 | 80 | 38.8 |
Petrovic | 2008 | Slovenia | Caucasians | 53.3 | 60.1 | Yes | 65.2 ± 9.9 | 66.9 ± 11.5 | 7 | Fundus photographs | Allele-specific PCR | 195 | 143 | 42.3 |
Zhou | 2010 | China | Asians | 49.0 | 48.0 | No | 55.6 ± 8.8 | 55.3 ± 8.6 | 6 | Ophthalmoscopy and fluorescein angiography | PCR-RFLP | 102 | 150 | 33.0 |
Zhu | 2010 | China | Asians | NA | NA | Yes | NA | NA | 6 | Ophthalmoscopy and fluorescein angiography | PCR-RFLP | 40 | 30 | 16.7 |
Balasubbu | 2010 | India | Asians | 30.0 | 42.0 | Yes | 57 ± 9 | 59 ± 11 | 7 | Ophthalmoscopy and fundus photographs | SNaPshot PCR | 345 | 359 | 48.2 |
Vinita | 2012 | India | Asians | 35.7 | 37.6 | Yes | 58.8 ± 8.6 | 64.3 ± 9.0 | 8 | Fundus photographs | DNA sequencing | 199 | 157 | 54.8 |
Lv | 2016 | China | Asians | 56.3 | 52.6 | Yes | 62.4 ± 11.9 | 60.2 ± 11.7 | 7 | Fundus photographs | PCR-LDR | 448 | 344 | 29.4 |
Li | 2016 | China | Asians | PDR: 51.7 NPDR: 46.2 | 43.8 | Yes | PDR: 66.9 ± 6.9 NPDR: 63.1 ± 6.8 | 54–82 | 7 | NA | DNA sequencing | 250 | 87 | 41.4 |