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Fig. 5 | BMC Ophthalmology

Fig. 5

From: Mitochondria-targeted antioxidant SKQ1 protects cornea from oxidative damage induced by ultraviolet irradiation and mechanical injury

Fig. 5

Morphology of cornea after UV irradiation upon premedication with SkQ1. Representative microscopic images of hematoxylin and eosin staining of normal rabbit cornea (a) or rabbit corneas after irradiation with 312 nm UV light (halogen lamp, 8 W) for 4 days, 20 min per day (b-e). Corneas one day after the last irradiation session with (d, e) or without (b, c) premedication with 7.5 μM SkQ1. Ep - corneal epithelium (if the designation Ep is absent, a complete loss of corneal epithelium is observed in preparation), Str - stroma, DM - Descemet’s membrane (if the designation DM is absent, the cornea in course of edematous changes became so thick that Descemet’s membrane and endothelium did not not fit in picture size). Pyknotic changes (apoptosis) in keratocytes are shown by black arrows. Granulocytic infiltration in stroma and anterior eye chamber is shown by red arrows. Due to abundance of pyknotic nuclei and granulocytes, not every one of them is labeled). Black arrowheads label an area of decrease in number of epithelial cell layers. Magnification ✕200 (A, B, D), ✕400 (c, e); scale bar 100 μm (a, b, d), 50 μm (c, e)

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