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Table 3 Mean changes in central macular thickness (CMT) in naïve and non-naïve patients. P values, between naïve and non-naïve patients, were calculated using the Mann–Whitney U test (statistical significance P < 0.05)

From: Intravitreal dexamethasone implant Ozurdex® in naïve and refractory patients with different subtypes of diabetic macular edema

 

Naïve

Non-Naïve

p

DifCMTM2, μm

 Mean

157.7

107.2

0.3714

 95% CI

77.4 to 237.9

75.5 to 138.8

 

DifCMTM4, μm

 Mean

132.4

68.8*

0.4158

 95% CI

55.4 to 209.3

35.8 to 101.7

 

DifCMTM6, μm

 Mean

126.9

90.7

0.2899

 95% CI

62.0 to 191.8

56.6 to 124.7

 

Intragroup Significance**

0.265

0.007

 
  1. DifCMTM difference in central macular thickness at month, CI confidence interval
  2. *In the Non-naïve patients, the change in central macular thickness between months 2 and 4 was significantly different (Bonferroni corrected, p = 0.0016)
  3. **In the naïve patients the change in macular thickness was stable and maintained over the course of follow-up. Whereas, in the non-naïve group there was a statistically significant difference between month 2 and 4. Repeated measures ANOVA and the Greenhouse-Geisser correction (Intragroup comparison)