Table 1 Main characteristics of the included studies
First author | Publication year | Design | MH stage | Sample size(Patients) | Group size(Eyes) | Average age | Gender ratio (Male/female) | Duration of FDP | Details of the surgical procedure | Intra- and postoperative evaluating parameters | Follow-up periods | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
FDP/NSP | FDP/NSP | FDP | NSP | |||||||||
Alberti, M | 2016 | RCT | Stage 2 3 4 | 68 | 34/34 | (69.8 ± 6.9) / (69.3 ± 5.7) | 3/12 | 9/6 | 3 days | 23-G PPV with the fill of 15%C3F8 and the peel of ILM. | Postoperative BCVA, MH closure rate, complications | 3 months |
Alberti, M | 2015 | Retrospective study | Stage 2 3 4 | 117 | 66/56 | (70.4 ± 6.8) / (69.5 ± 5.8) | 22/44 | 21/36 | 3 days | 23-G PPV with the fill of 15%C3F8 and the peel of ILM. | Postoperative BCVA, MH closure rate, complications | 6 months |
Feist, RM | 2014 | Retrospective study | NA | 82 | 57/25 | NA | 27/35 | 11/14 | 3 days | PPV with the fill of C3F8 or SF6 and the peel of ILM. | Postoperative BCVA, MH closure rate, complications | NA |
Forsaa, VA | 2013 | Retrospective study | Stage 2 3 4 | 64 | 33/34 | (68.4 ± 9.0) / (71.7 ± 6.8) | 8/2 | 4/5 | 3 days | 23-G PPV with the fill of 22–30%SF6 or 16–20%C2F6 and the peel of ILM. | Postoperative BCVA, MH closure rate, complications | 4.7–19.8 months |
Yorston, D | 2012 | RCT | Stage 2 3 4 | 30 | 16/14 | (71.1 ± 5.9) / (68.0 ± 5.6) | 1/15 | 0/14 | 10 days | 20-G PPV with the fill of 14%C3F8 and the peel of ILM.The phacoemulsification with introcular lens insertion was carried out. | Postoperative BCVA, MH closure rate, complications | 6 months |
Lange, CA | 2012 | RCT | Stage 2 3 4 | 30 | 15/15 | (66.8 ± 5.9) / (71.0 ± 6.2) | 7/11 | 11/6 | 10 days | 20-G PPV with the fill of 14%C3F8 and the peel of ILM. | Postoperative BCVA, MH closure rate, complications | 6–8 weeks |
Tadayoni, R | 2011 | RCT | ≤400 μm | 69 | 34/35 | (67.31 ± 6.46) / (66.31 ± 6.51) | 11/23 | 15/20 | 10 days | PPV with the fill of 17%C2F6. | Postoperative BCVA, MH closure rate, complications | 3 months |
Guillaubey, A | 2008 | RCT | Stage 2 3 4 | 144 | 72/78 | (55.7 ± 9.9) / (55.7 ± 7.4) | 25/47 | 27/51 | 10 days | 20-G PPV with the fill of 14%C3F8, 17%C2F6 or 20%SF6 and the peel of ILM.When needed, 62/150 had phacovitrectomy. | Postoperative BCVA, MH closure rate, complications | 6 months |
Tranos, PG | 2007 | RCT | Stage 2 3 4 | 41 | 25/16 | NA | NA | NA | 10 days | 20-G PPV with the fill of 16%C3F8 and the peel of ILM. | Postoperative BCVA, MH closure rate, 25-Visual Function Questionnaire(VFQ-25) and complications | 4 months |
Simcock, PR | 2001 | Non-randomised historically controlled study | Stage 2 3 | 33 | 13/20 | NA | 2/11 | 5/15 | 10 days | PPV with the fill of 20% C2F6.phacoemulsification with introcular lens insertion was combined. | Postoperative BCVA, MH closure rate, complications | 3 months |
Szurman, P | 2000 | Consecutive case control study | Stage 2 3 4 | 50 | 25/25 | (67 ± 5.6) / (67 ± 4.2) | 6/19 | 6/19 | 14 days | PPV with fill of 20%SF6 or 16% C3F8. | Postoperative BCVA, MH closure rate, complications | 6–12 months |