Skip to main content

Advertisement

Fig. 3 | BMC Ophthalmology

Fig. 3

From: Evaluation of the antioxidant effects of different histone deacetylase inhibitors (HDACis) on human lens epithelial cells (HLECs) after UVB exposure

Fig. 3

Effects of HDACi on the expressions of Bcl-2, BAX, caspase-3, SOD1, FOXO3A and MT2 mRNA in UVB-treated HLECs. BAX: a-d, FOXO3A: e-h, Caspase3: i-l, MT2:m-p, Bcl-2: q-t, SOD1: u-x. βOHB (4 mmol/L) and TSA (0.2 mol/L) had protective effects on BCL-2 expression. TSA (0.2 mol/L) had a protective effect on SOD1 expression. TSA (0.2 mol/L) and SAHA (1 μmol/L) suppressed BAX and caspase-3 expression. TSA (0.2 mol/L, 0.8 mol/L) and SAHA (1 μmol/L, 2 μmol/L) suppressed the expression of FOXO3A and MT2. The HDACi-induced protective effects were not strictly dose-dependent. * P < 0.05

Back to article page