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Table 1 Characteristics of infants with Type 1 ROP after the post-menstrual age of 40 weeks

From: Ranibizumab injection and laser photocoagulation to treat type 1 retinopathy of prematurity after 40 weeks post menstrual age: a retrospective case series study

Variables

All infants

Comparison between Group 1 and 2

 

Group 1

Group 2

p value

 

(Primary IVR)

(Primary laser)

 

Patients, n

14

9

5

/

Male, n (%)

8

7 (78%)

0 (0%)

0.021* (Fisher’s exact test)

GA, weeks (mean ± SD)

28.9 ± 2.3

29.0 ± 2.2

28.8 ± 2.6

0.882 (Student t-test)

(range)

(26.0–33.0)

(27.0–33.0)

(26.0–32.0)

 

BW, grams (mean ± SD)

1227.1 ± 347.9

1200.5 ± 360.3

1275.0 ± 359.6

0.717 (Student t-test)

(range)

(815–2000)

(815–2000)

(980–1800)

 

PMA at diagnosis, weeks [mean ± SD (range)]

41.4 ± 2.2

40.8 ± 1.0 (40–43)

42.6 ± 3.4 (40–48)

0.518 (Mann-Whitney test)

Follow-up, months [mean ± SD (range)]

12.5 ± 6.9 (6–24)

11.0 ± 5.9 (6–24)

15.2 ± 8.3 (6–24)

0.290 (Student t-test)

Eyes, n

27

17

10

 

Zone 2 stage 3 with plus, n (%)

20

14 (82%)

6 (60%)

0.365 (Pearson’s Chi-squared test)

Zone 2 stage 2 with plus, n (%)

7

3 (18%)

4 (40%)

/

Posterior zone 2 disease

 

12 (86%)

0 (0)

< 0.001(Fisher’s exact test)

Fibrotic ridges, n (%)

17

12 (70%)

5 (50%)

0.415

Hemorrhage on fibrovascular ridge, n, (%)

11

10 (59%)

1 (10%)

0.018* (Fisher’s exact test)

  1. BW birth weight, DD disc diameter, GA gestational age, IVR intravitreal injection of ranibizumab, PMA postmenstrual age, ROP retinopathy of prematurity, SD standard deviation
  2. *significant between-group difference