TY - JOUR AU - Lim, L. S. AU - Mitchell, P. AU - Seddon, J. M. AU - Holz, F. G. AU - Wong, T. Y. PY - 2012 DA - 2012// TI - Age-related macular degeneration JO - Lancet. VL - 379 UR - https://doi.org/10.1016/S0140-6736(12)60282-7 DO - 10.1016/S0140-6736(12)60282-7 ID - Lim2012 ER - TY - JOUR AU - Abdelsalam, A. AU - Priore, L. AU - Zarbin, M. A. PY - 1999 DA - 1999// TI - Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression JO - Surv Ophthalmol VL - 44 UR - https://doi.org/10.1016/S0039-6257(99)00072-7 DO - 10.1016/S0039-6257(99)00072-7 ID - Abdelsalam1999 ER - TY - STD TI - Hamley IW. The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization. 2012 ;112(10):5147–92. doi: https://doi.org/10.1021/cr3000994. ID - ref3 ER - TY - JOUR AU - Ratnayaka, J. A. AU - Serpell, L. C. AU - Lotery, A. J. PY - 2015 DA - 2015// TI - Dementia of the eye: the role of amyloid beta in retinal degeneration JO - Eye (Lond) VL - 29 UR - https://doi.org/10.1038/eye.2015.100 DO - 10.1038/eye.2015.100 ID - Ratnayaka2015 ER - TY - JOUR AU - Ohno-Matsui, K. PY - 2011 DA - 2011// TI - Parallel findings in age-related macular degeneration and Alzheimer's disease JO - Prog Retin Eye Res VL - 30 UR - https://doi.org/10.1016/j.preteyeres.2011.02.004 DO - 10.1016/j.preteyeres.2011.02.004 ID - Ohno-Matsui2011 ER - TY - STD TI - Dahlgren KN, Manelli AM, Stine WB Jr, Baker LK, Krafft GA, LaDu MJ. Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J Biol Chem 2002;30;277(35):32046–32053. ID - ref6 ER - TY - JOUR AU - Isas, J. M. AU - Luibl, V. AU - Johnson, L. V. AU - Kayed, R. AU - Wetzel, R. AU - Glabe, C. G. AU - Langen, R. AU - Chen, J. PY - 2010 DA - 2010// TI - Soluble and mature amyloid fibrils in drusen deposits JO - Invest Ophthalmol Vis Sci VL - 51 UR - https://doi.org/10.1167/iovs.09-4207 DO - 10.1167/iovs.09-4207 ID - Isas2010 ER - TY - JOUR AU - Liu, R. T. AU - Wang, A. AU - Gao, J. AU - Cao, S. AU - Cui, J. Z. AU - Matsubara, J. A. PY - 2014 DA - 2014// TI - Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells JO - Exp Eye Res VL - 127 UR - https://doi.org/10.1016/j.exer.2014.07.003 DO - 10.1016/j.exer.2014.07.003 ID - Liu2014 ER - TY - STD TI - Liu RT, Gao J, Cao S, Sandhu N, Cui JZ, Chou CL, Fang E, Matsubara JA. Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration. Invest Ophthalmol Vis Sci 2013 1;54(3):2225–2237. doi: https://doi.org/10.1167/iovs.12-10849. ID - ref9 ER - TY - JOUR AU - Yoshikawa, T. AU - Ogata, N. AU - Izuta, H. AU - Shimazawa, M. AU - Hara, H. AU - Takahashi, K. PY - 2011 DA - 2011// TI - Increased expression of tight junctions in ARPE-19 cells under endoplasmic reticulum stress JO - Curr Eye Res VL - 36 UR - https://doi.org/10.3109/02713683.2011.606592 DO - 10.3109/02713683.2011.606592 ID - Yoshikawa2011 ER - TY - JOUR AU - Masui, T. AU - Ota, I. AU - Itaya-Hironaka, A. AU - Takeda, M. AU - Kasai, T. AU - Yamauchi, A. AU - Sakuramoto-Tsuchida, S. AU - Mikami, S. AU - Yane, K. AU - Takasawa, S. AU - Hosoi, H. PY - 2013 DA - 2013// TI - Expression of REG III and prognosis in head and neck cancer JO - Oncol Rep VL - 30 UR - https://doi.org/10.3892/or.2013.2521 DO - 10.3892/or.2013.2521 ID - Masui2013 ER - TY - STD TI - Kyotani Y, Ota H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Zhao J, Ozawa K, Nagayama K, Ito S, Takasawa S, Kimura H, Uno M, Yoshizumi M. Intermittent hypoxia induces the proliferation of rat vascular smooth muscle cell with the increases in epidermal growth factor family and erbB2 receptor. Exp Cell Res 2013 15;319(19):3042–3050. doi: https://doi.org/10.1016/j.yexcr.2013.08.014. ID - ref12 ER - TY - STD TI - Ota H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Miyaoka T, Fujimura T, Tsujinaka H, Yoshimoto K, Nakagawara K, Tamaki S, Takasawa S, Kimura H. Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene. Life Sci 2013 4;93(18–19):664–672. doi: https://doi.org/10.1016/j.lfs.2013.09.001. ID - ref13 ER - TY - JOUR AU - Saveljeva, S. AU - Mc Laughlin, S. L. AU - Vandenabeele, P. AU - Samali, A. AU - Bertrand, M. J. PY - 2015 DA - 2015// TI - Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells JO - Cell Death Dis VL - 8 UR - https://doi.org/10.1038/cddis DO - 10.1038/cddis ID - Saveljeva2015 ER - TY - JOUR AU - Chandra, D. AU - Choy, G. AU - Deng, X. AU - Bhatia, B. AU - Daniel, P. AU - Tang, D. G. PY - 2004 DA - 2004// TI - Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death JO - Mol Cell Biol VL - 24 UR - https://doi.org/10.1128/MCB.24.15.6592-6607.2004 DO - 10.1128/MCB.24.15.6592-6607.2004 ID - Chandra2004 ER - TY - STD TI - Kobayashi S, Akiyama T, Nata K, Abe M, Tajima M, Shervani NJ, Unno M, Matsuno S, Sasaki H, Takasawa S, Okamoto H. Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor. J Biol Chem 2000 14;275(15):10723–10726. ID - ref16 ER - TY - JOUR AU - Shervani, N. J. AU - Takasawa, S. AU - Uchigata, Y. AU - Akiyama, T. AU - Nakagawa, K. AU - Noguchi, N. AU - Takada, H. AU - Takahashi, I. AU - Yamauchi, A. AU - Ikeda, T. AU - Iwamoto, Y. AU - Nata, K. AU - Okamoto, H. PY - 2004 DA - 2004// TI - Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients JO - Eur J Clin Investig VL - 34 UR - https://doi.org/10.1111/j.1365-2362.2004.01419.x DO - 10.1111/j.1365-2362.2004.01419.x ID - Shervani2004 ER - TY - STD TI - Ota H, Tamaki S, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Morioka T, Takasawa S, Kimura H. Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38. Life Sci 2012 30;90(5–6):206–211. doi: https://doi.org/10.1016/j.lfs.2011.11.011. ID - ref18 ER - TY - JOUR AU - Nakagawa, K. AU - Takasawa, S. AU - Nata, K. AU - Yamauchi, A. AU - Itaya-Hironaka, A. AU - Ota, H. AU - Yoshimoto, K. AU - Sakuramoto-Tsuchida, S. AU - Miyaoka, T. AU - Takeda, M. AU - Unno, M. AU - Okamoto, H. PY - 2013 DA - 2013// TI - Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation JO - Biochim Biophys Acta VL - 1833 UR - https://doi.org/10.1016/j.bbamcr.2013.08.004 DO - 10.1016/j.bbamcr.2013.08.004 ID - Nakagawa2013 ER - TY - JOUR AU - Yoshimoto, K. AU - Fujimoto, T. AU - Itaya-Hironaka, A. AU - Miyaoka, T. AU - Sakuramoto-Tsuchida, S. AU - Yamauchi, A. AU - Takeda, M. AU - Kasai, T. AU - Nakagawara, K. AU - Nonomura, A. AU - Takasawa, S. PY - 2013 DA - 2013// TI - Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjögren’s syndrome JO - Clin Exp Immunol VL - 174 UR - https://doi.org/10.1111/cei.12142 DO - 10.1111/cei.12142 ID - Yoshimoto2013 ER - TY - JOUR AU - Murakami-Kawaguchi, S. AU - Takasawa, S. AU - Onogawa, T. AU - Nata, K. AU - Itaya-Hironaka, A. AU - Sakuramoto-Tsuchida, S. AU - Yamauchi, A. AU - Ota, H. AU - Takeda, M. AU - Kato, M. AU - Okamoto, H. PY - 2014 DA - 2014// TI - Expression of Ins1 and Ins2 genes in mouse fetal liver JO - Cell Tissue Res VL - 355 UR - https://doi.org/10.1007/s00441-013-1741-4 DO - 10.1007/s00441-013-1741-4 ID - Murakami-Kawaguchi2014 ER - TY - JOUR AU - Witmer, A. N. AU - Vrensen, G. F. AU - Noorden, C. J. AU - Schlingemann, R. O. PY - 2003 DA - 2003// TI - Vascular endothelial growth factors and angiogenesis in eye disease JO - Prog Retin Eye Res VL - 22 UR - https://doi.org/10.1016/S1350-9462(02)00043-5 DO - 10.1016/S1350-9462(02)00043-5 ID - Witmer2003 ER - TY - JOUR AU - Haass, C. AU - Selkoe, D. J. PY - 2007 DA - 2007// TI - Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide JO - Nat Rev Mol Cell Biol VL - 8 UR - https://doi.org/10.1038/nrm2101 DO - 10.1038/nrm2101 ID - Haass2007 ER - TY - JOUR AU - Luo, Y. AU - Bolon, B. AU - Damore, M. A. AU - Fitzpatrick, D. AU - Liu, H. AU - Zhang, J. AU - Yan, Q. AU - Vassar, R. AU - Citron, M. PY - 2003 DA - 2003// TI - BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time JO - Neurobiol Dis VL - 14 UR - https://doi.org/10.1016/S0969-9961(03)00104-9 DO - 10.1016/S0969-9961(03)00104-9 ID - Luo2003 ER - TY - JOUR AU - Zou, K. AU - Gong, J. S. AU - Yanagisawa, K. AU - Michikawa, M. PY - 2002 DA - 2002// TI - A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage JO - J Neurosci VL - 22 UR - https://doi.org/10.1523/JNEUROSCI.22-12-04833.2002 DO - 10.1523/JNEUROSCI.22-12-04833.2002 ID - Zou2002 ER - TY - STD TI - Baruch-Suchodolsky R, Fischer B. Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems. Biochemistry. 2009;26;48(20):4354–4370. doi: https://doi.org/10.1021/bi802361k. ID - ref26 ER - TY - STD TI - Prasad T, Zhu P, Verma A, Chakrabarty P, Rosario AM, Golde TE, Li Q. Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice. Sci Rep 2017 12;7(1):3222. doi: https://doi.org/10.1038/s41598-017-03397-2. ID - ref27 ER - TY - JOUR AU - Sun, J. AU - Huang, P. AU - Liang, J. AU - Li, J. AU - Shen, M. AU - She, X. AU - Feng, Y. AU - Luo, X. AU - Liu, T. AU - Sun, X. PY - 2017 DA - 2017// TI - Cooperation of Rel family members in regulating Aβ1-40-mediated pro-inflammatory cytokine secretion by retinal pigment epithelial cells JO - Cell Death Dis VL - 8 UR - https://doi.org/10.1038/cddis.2017.502 DO - 10.1038/cddis.2017.502 ID - Sun2017 ER - TY - JOUR AU - Lynn, S. A. AU - Keeling, E. AU - Munday, R. AU - Gabha, G. AU - Griffiths, H. AU - Lotery, A. J. AU - Ratnayaka, J. A. PY - 2017 DA - 2017// TI - The complexities underlying age-related macular degeneration: could amyloid beta play an important role? JO - Neural Regen Res VL - 12 UR - https://doi.org/10.4103/1673-5374.205083 DO - 10.4103/1673-5374.205083 ID - Lynn2017 ER - TY - JOUR AU - Yamamoto, Y. AU - Kato, I. AU - Doi, T. AU - Yonekura, H. AU - Ohashi, S. AU - Takeuchi, M. AU - Watanabe, T. AU - Yamagishi, S. AU - Sakurai, S. AU - Takasawa, S. AU - Okamoto, H. AU - Yamamoto, H. PY - 2001 DA - 2001// TI - Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice JO - J Clin Invest VL - 108 UR - https://doi.org/10.1172/JCI11771 DO - 10.1172/JCI11771 ID - Yamamoto2001 ER - TY - JOUR AU - Tsujinaka, H. AU - Itaya-Hironaka, A. AU - Yamauchi, A. AU - Sakuramoto-Tsuchida, S. AU - Ota, H. AU - Takeda, M. AU - Fujimura, T. AU - Takasawa, S. AU - Ogata, N. PY - 2015 DA - 2015// TI - Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation of VEGF gene JO - Biochem Biophys Rep VL - 29 UR - https://doi.org/10.1016/j.bbrep.2015.05.005 DO - 10.1016/j.bbrep.2015.05.005 ID - Tsujinaka2015 ER - TY - JOUR AU - Ma, W. AU - Lee, S. E. AU - Guo, J. AU - Qu, W. AU - Hudson, B. I. AU - Schmidt, A. M. AU - Barile, G. R. PY - 2007 DA - 2007// TI - RAGE ligand upregulation of VEGF secretion in ARPE-19 cells JO - Invest Ophthalmol Vis Sci VL - 48 UR - https://doi.org/10.1167/iovs.06-0738 DO - 10.1167/iovs.06-0738 ID - Ma2007 ER - TY - JOUR AU - Yoshida, T. AU - Ohno-Matsui, K. AU - Ichinose, S. AU - Sato, T. AU - Iwata, N. AU - Saido, T. C. AU - Hisatomi, T. AU - Mochizuki, M. AU - Morita, I. PY - 2005 DA - 2005// TI - The potential role of amyloid beta in the pathogenesis of age-related macular degeneration JO - J Clin Invest VL - 115 UR - https://doi.org/10.1172/JCI24635 DO - 10.1172/JCI24635 ID - Yoshida2005 ER - TY - JOUR AU - Tombran-Tink, J. AU - Chader, G. G. AU - Johnson, L. V. PY - 1991 DA - 1991// TI - PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity JO - Exp Eye Res VL - 53 UR - https://doi.org/10.1016/0014-4835(91)90248-D DO - 10.1016/0014-4835(91)90248-D ID - Tombran-Tink1991 ER - TY - JOUR AU - Ogata, N. AU - Wada, M. AU - Otsuji, T. AU - Jo, N. AU - Tombran-Tink, J. AU - Matsumura, M. PY - 2002 DA - 2002// TI - Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal JO - Invest Ophthalmol Vis Sci VL - 43 ID - Ogata2002 ER - TY - JOUR AU - Matsuoka, M. AU - Ogata, N. AU - Otsuji, T. AU - Nishimura, T. AU - Takahashi, K. AU - Matsumura, M. PY - 2004 DA - 2004// TI - Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy JO - Br J Ophthalmol VL - 88 UR - https://doi.org/10.1136/bjo.2003.032466 DO - 10.1136/bjo.2003.032466 ID - Matsuoka2004 ER - TY - JOUR AU - Wang, Y. AU - Subramanian, P. AU - Shen, D. AU - Tuo, J. AU - Becerra, S. P. AU - Chan, C. C. PY - 2013 DA - 2013// TI - Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration JO - ASN Neuro VL - 5 UR - https://doi.org/10.1042/AN20130028 DO - 10.1042/AN20130028 ID - Wang2013 ER - TY - JOUR AU - Green, W. R. AU - Key, S. N. PY - 1977 DA - 1977// TI - Senile macular degeneration: a histopathologic study JO - Trans Am Ophthalmol Soc VL - 75 ID - Green1977 ER - TY - JOUR AU - Ishibashi, Y. AU - Matsui, T. AU - Ohta, K. AU - Tanoue, R. AU - Takeuchi, M. AU - Asanuma, K. AU - Fukami, K. AU - Okuda, S. AU - Nakamura, K. AU - Yamagishi, S. PY - 2013 DA - 2013// TI - PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation JO - Microvasc Res VL - 85 UR - https://doi.org/10.1016/j.mvr.2012.10.007 DO - 10.1016/j.mvr.2012.10.007 ID - Ishibashi2013 ER - TY - JOUR AU - Wang, J. AU - Ohno-Matsui, K. AU - Nakahama, K. AU - Okamoto, A. AU - Yoshida, T. AU - Shimada, N. AU - Mochizuki, M. AU - Morita, I. PY - 2011 DA - 2011// TI - Amyloid beta enhances migration of endothelial progenitor cells by upregulating CX3CR1 in response to fractalkine, which may be associated with development of choroidal neovascularization JO - Arterioscler Thromb Vasc Biol VL - 31 UR - https://doi.org/10.1161/ATVBAHA.110.215517 DO - 10.1161/ATVBAHA.110.215517 ID - Wang2011 ER - TY - STD TI - Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature. 2016;1;537(7618):50–56. doi: https://doi.org/10.1038/nature19323. ID - ref41 ER -