Fig. 1

The multimodal images of case 1, a 46 year-old Chinese female with CSC and FCE. a. at baseline, the fundus showed serous detachment and depigmentation zone nasal to it at the macular. b. The OCT presented with SRF and FCE. The region temporal to FCE presented with flat irregular pigment epithelial detachment (PED). The choroidal thickness (CT) on fovea and underlying FCE was 338 μm and 202 μm. c, d. The FA from early phase to the middle showed classic inkblot leakage. The PDT irradiation was labeled in a red circle, with a diameter of 2500 μm. e. One month post-PDT, the OCT presented with complete resolution of SRF and RPE decompensation underlying FCE. The CT on fovea and underlying FCE was 315 μm and 183 μm. f. At 2 months, the reflection of RPE on OCT became clear. The CT on fovea and underlying FCE was 285 μm and 168 μm. g. At 3 months, the fundus presented with macular edema and still existed hypopigmentation zone. h. The OCT presented with a new lesion of CNV through RPE/Bruch complex and sub-retinal fluid. The CT on fovea and underlying FCE was 289 μm and 175 μm. i. The early phase FA showed “lacy” hypofluorescence around slightly- hyperfluorescence areas. j. The middle phase FA showed the obvious but focal fluorescence leaking in CNV lesion. k. One month post intravitreal injection, the OCT presented with RPE elevation with hyperreflective material in once CNV lesion, and only a little residue FCE nasal to the scar. The CT on fovea and underlying FCE was 282 μm and 172 μm. l. Two months post injection, the OCT images presented little changes, compared with last visit. The CT on fovea and underlying FCE was 280 μm and 171 μm. The best corrected visual acuity (BCVA) was 10/20 throughout the whole follow-up