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Table 2 Comparison of the application method of UV / riboflavin and parameter values in standard Dresden and accelerated cross-linking of previous studies. The first three studies used pulsed UV irradiation, while the others used continuous UV

From: Effect of the retention ring-assisted continuous application of riboflavin in pulsed-light accelerated corneal collagen cross-linking on the progression of keratoconus

 

Irradiation*

Total Dose* (J/cm2)

Riboflavin application*: before/during irradiation

FU (mo.)

Standard Dresden Protocol

Accelerated Protocol

N

Δ BCVA (logMAR)

Δ Kmax (diopter)

Δ CCT (μm)

Δ ECD (cell/cm2)

DDL (μm)

N

Δ BCVA (logMAR)

Δ Kmax (diopter)

Δ CCT (μm)

Δ ECD (cell/cm2)

DDL (μm)

Our study

30 mW/cm2 for 8 min

(1 s. on/off)

7.2

with HMPC for 10 min, ontinuous / Not applied

12

Not available

20

−0.25

−1.54

− 10.3

−91

281

Mazzotta [20]

15 mW/cm2 for 12 min (1 s. on/off)

5.4

with HMPC every 1 min for 10 min

/ NR

24

Not available

132

− 0.14

−0.42

5.03

NR

280

Jiang [19]

30 mW/cm2 for 8 min (1 s. on/off)

7.2

with HMPC every 2 min for 10 min

/ every 3 min

12

31

− 0.12

−1.80

NR

− 109

285

36

−0.09

−1.31

NR

−247

202

Bouheraoua [24]

30 mW/cm2 for 3 min

5.4

20% dextran every 1 min for 10 min / NR

6

15

−0.05

−1.80

−1

+ 4

303

15

−0.01

0.50

−3

20

184

Brittingham [25]

9 mW/cm2 for 10 min

5.4

20% dextran every 5 min for 20 min / every 2 min

12

81

NR

−0.76

NR

NR

323

50

NR

0.72

NR

NR

245

Hagem [26]

9 mW/cm2 for 10 min

5.4

with HPMC for 20 min

/ every 2 min

12

20

−0.11

−1.40

NR

− 112

442

20

−0.09

−0.50

NR

−54

317

Ng [27]

9 mW/cm2 for 10 min

5.4

20% dextran every 2 min for 25 min / every 5 min

13.9

14

−0.13

−1.80

−2.1

NR

283

12

0.02

−0.30

2.1

NR

209

Shetty [8]

18 mW/cm2 for 5 min

5.4

20% dextran every 2 min for 30 min / every 2 min

15.3

36

0.04 (decimal)

−1.32

NR

− 166

280

33

0.10 (decimal)

−0.52

NR

− 162

203

  1. *Irradiation and riboflavin application method of accelerated protocol, Values are presented as mean value, FU, follow up; N, number; mo, months; BCVA, best-corrected visual acuity; logMAR, logarithm of minimum angle of resolution; Kmax, maximum keratometry; CCT, central corneal thickness; ECD, endothelial cell density; DDL, depth of demarcation line; NR, not reported; ΔBCVA (logMAR), BCVA at last FU - preoperative BCVA; ΔKmax, Kmax at last FU - preoperative Kmax; ΔCCT, CCT at last FU - preoperative CCT; ΔECC, ECC at last FU - preoperative ECC