BMC Ophthalmology

Table 2 Periodic changes in pathomorphologic findings from fundus

From: Intravitreal dexamethasone implant for central retinal vein occlusion without macular edema

	Observation group		IVD-treated group		p-value
	Mean	SD	Mean	SD	p-value
Vascular tortuosity (μm/μm)
Superior
Baseline	0.24	0.14	0.34	0.20	0.78*
1 month	0.24	0.09	0.25	0.06	0.90*
3 months	0.21	0.08	0.20	0.07	0.98*
6 months	0.19	0.07	0.18	0.07	0.87*
12 months	0.18	0.05	0.17	0.07	0.89*
p-value	0.094^†		0.025 ^†		0.014 ^‡
Inferior
Baseline	0.50	0.15	0.67	0.45	0.13*
1 month	0.46	0.18	0.40	0.31	0.26*
3 months	0.38	0.13	0.30	0.24	0.15*
6 months	0.34	0.12	0.30	0.30	0.59*
12 months	0.33	0.15	0.18	0.13	0.14*
p-value	0.059^†		0.002 ^†		0.036 ^‡
Vascular width (μm)
Superior
Baseline	297.28	69.87	310.13	79.89	0.12*
1 month	288.45	68.61	266.94	71.33	0.020*
3 months	273.33	54.78	262.47	55.37	0.13*
6 months	270.71	47.81	252.53	51.64	0.39*
12 months	238.37	70.56	245.03	58.82	0.48*
p-value	0.014 ^†		0.007 ^†		0.024 ^‡
Inferior
Baseline	285.30	68.63	295.05	88.79	0.13*
1 month	288.85	47.55	258.60	59.37	0.012*
3 months	250.22	49.02	236.21	50.38	0.062*
6 months	248.00	37.73	216.44	69.29	0.26*
12 months	227.01	49.21	213.20	48.21	0.22*
p-value	0.11^†		0.001 ^†		0.003 ^‡
Retinal hemorrhage (score)
Baseline	20.60	15.38	27.70	9.70	0.052*
1 month	19.62	11.63	12.50	10.30	0.20*
3 months	12.22	8.52	8.01	9.00	0.062*
6 months	11.20	8.24	7.40	5.86	0.18*
12 months	8.24	4.75	3.16	4.88	0.062*
p-value	0.010 ^†		< 0.001 ^†		0.006 ^‡
Cotton wool spots (number)
Baseline	3.75	2.79	3.89	3.28	0.24*
1 month	2.75	2.10	2.11	3.10	0.67*
3 months	2.33	0.22	2.03	0.15	0.66*
6 months	2.12	0.38	2.01	0.34	0.74*
12 months	1.18	0.40	1.22	0.60	0.76*
p-value	0.004 ^†		0.002 ^†		0.42^‡

Analysis used *Mann-Whitney U test to compare groups at each time-point; ^†Wilcoxon signed-rank test to compare baseline and endpoints within a group; and ^‡generalized estimating equation to compare changes with time between the groups
IVD intravitreal dexamethasone
The bold font for P-values indicates a statistical significance (i.e., P < .05)

Back to article page

ISSN: 1471-2415

Contact us

General enquiries: journalsubmissions@springernature.com