Correlation of retinal layer changes with vision gain in diabetic macular edema during conbercept treatment

BMC Ophthalmology

Table 2 Correlation for BCVA gain after 1 year conbercept treatment and individual layer thickness changes from different regions

Region	RNFL		GCL		IPL		INL		OPL		ONL		PR
Region	Correlation Coefficient r	p	Correlation Coefficient r	p	Correlation Coefficient r	p	Correlation Coefficient r	p	Correlation Coefficient r	p	Correlation Coefficient r	p	Correlation Coefficient r	p
Average	0.389	0.090	0.415	0.069	0.473	0.035	0.411	0.072	0.371	0.107	0.495	0.026	0.190	0.422
Central	0.558	0.011	0.591	0.006	0.663	0.001	0.116	0.626	0.458	0.042	0.459	0.019	0.288	0.218
I.S.	0.478	0.033	0.039	0.869	0.017	0.943	0.322	0.167	0.35	0.131	0.429	0.059	0.115	0.628
I.I.	0.003	0.990	0.215	0.362	0.291	0.214	0.338	0.145	0.064	0.789	0.465	0.039	0.159	0.504
I.N.	0.402	0.079	0.01	0.967	0.552	0.012	0.206	0.384	0.113	0.635	0.494	0.027	0.212	0.370
I.T.	0.453	0.045	0.088	0.711	0.283	0.226	0.232	0.326	0.231	0.326	0.363	0.116	0.163	0.492
O.S.	0.44	0.052	0.563	0.010	0.137	0.563	0.080	0.736	0.441	0.052	0.378	0.100	0.469	0.037
O.I.	0.412	0.071	0.408	0.074	0.678	0.001	0.604	0.005	0.344	0.137	0.469	0.037	0.225	0.341
O.N.	0.234	0.322	0.227	0.336	0.527	0.017	0.488	0.029	0.300	0.198	0.444	0.049	0.183	0.441
O.T.	0.449	0.047	0.357	0.123	0.024	0.918	0.247	0.295	0.488	0.029	0.218	0.356	0.473	0.035

Significant p values are in bold
Region: Standard EDTRS grid are used with central subfield (r = 0.5 mm) (Central), inner ring(r = 0.5–1.5 mm) (I), outer ring(r = 1.5-3 mm) (O). Inner ring and outer ring are divided into four parts: superior part(S), inferior part (I), nasal part (N) and temporal part (T). I.S. stand for superior part of inner ring and so are the others
Dependent variable: Best-corrected vision acuity (BCVA) gain at the Final Visit
Explanatory variables: RNFL 1-year retinal nerve fiber layer thickness decrease, GCL 1-year ganglion cell layer thickness decrease, IPL 1-year inner plexiform layer thickness decrease, INL 1-year inner nuclear layer thickness decrease, OPL 1-year outer plexiform layer thickness decrease, ONL 1-year outer nuclear layer thickness decrease, PR 1-year photoreceptor-RPE-complex thickness decrease (external limiting membrane to Bruch’s membrane)

ISSN: 1471-2415