Correlation of retinal layer changes with vision gain in diabetic macular edema during conbercept treatment

BMC Ophthalmology

Table 3 Multivariate linear regression analysis of factors with influence on BCVA gain after 1 year conbercept treatment in central subfield

	Univariate Analysis		Multivariate Analysis (Adjusted R² = 0.544) ^a
	t	p	Unstandardized Regression Coefficient B	Standardized Regression Coefficient β	p
Constant			6.812		< 0.001
BL BCVA	0.509	0.617
IVTs	0.695	0.496
RNFL	−2.851	0.011
GCL	−3.105	0.006	1.752	0.414	0.022
IPL	−3.756	0.001	0.455	0.523	0.005
INL	−0.495	0.626
OPL	−2.184	0.042
ONL	−2.585	0.019
PR	−1.276	0.218

Significant p values are in bold. t = β/ Standard Error (SE)
Dependent variable: Best-corrected vision acuity (BCVA) gain at the Final Visit
Explanatory variables: BL BCVA Baseline best-corrected visual acuity, IVTs Number of intravitreal injections, RNFL 1-year retinal nerve fiber layer thickness decrease, GCL 1-year ganglion cell layer thickness decrease, IPL 1-year inner plexiform layer thickness decrease, INL 1-year inner nuclear layer thickness decrease, OPL 1-year outer plexiform layer thickness decrease, ONL 1-year outer nuclear layer thickness decrease, PR 1-year photoreceptor-RPE-complex thickness decrease (external limiting membrane to Bruch’s membrane)
^aAdjusted coefficient of multiple determination

ISSN: 1471-2415