Table 1 Summary of Rosai-Dorfman disease manifesting as epibulbar masses
Reference | Age/Gender | Eye | Ophthalmic findings | Extraocular involvement | Treatment | Recurrence |
|---|---|---|---|---|---|---|
Zimmerman, 1988 [6] | 13/M | OS | Superior epibulbar nodule (8 × 6 mm) | Minimal inguinal lymphadenopathy | Excision | No |
Tan, 2002 [7] | 63/M | OS | Inferior epibulbar nodule (5 × 12 mm), anterior modular scleritis, anterior and posterior uveitis | Post-auricular lymphadenopathy and vocal cord nodule | Excision + Oral & topical steroid | Yes |
Albini, 2005 [8] | 71/M | OD | Nasal side epibulbar nodule (15 × 15 mm) | Nil | Excision | No |
|  | 51/M | OS | Nasal side epibulbar nodule (5 mm) | Nil | Excision | No |
Sarwal, 2008 [9] | 53/F | OU | Superotemporal epibulbar nodule (3 × 3 mm), anterior nodular scleritis, anterior uveitis | Anterior chest wall, abdominal and pelvic masses | Excision + topical steroid | Yes |
|  | 19/F | OS | Superonasal epibulbar nodule (3.25 × 3.25 mm), nodular scleritis | Nil | Excision | No |
Fernandes, 2008 [10] | 19/M | OD | Temporal epibulbar nodule (12 × 11 mm), conjunctival injection | Nil | Excision | Yes |
Maheshwari, 2008 [11] | 17/M | OS | Temporal epibulbar nodule (3 × 5 mm) | Nil | Excision + oral steroid | No |
De Oliveira, 2011 [3] | 14/F | OD | Inferior epibulbar nodule (5 × 15 mm), conjunctival injection | Nil | Excision | No |
Payne, 2011 [4] | 20/F | OS | Inferonasal epibulbar nodule (5 × 5 mm), panuveitis, subretinal exudate | Pelvic mass | Excision + Oral & topical steroid | Yes |
Shah, 2012 [12] | 36/F | OS | Superior epibulbar nodule (12 × 20 mm), trace anterior uveitis | Nil | Excision + Oral & topical steroid + oral cyclosporine | Yes |
Choi, 2018 [2] | 35/M | OU | Epibulbar masses, retinal detachment, and choroidal effusions | Sinus, trachea, renal, subcutaneous skin lesions | Cladribine, steroids, mycophenolate mofetil, rituximab, vemurafenib | Yes |
| Â | 54/F | OU | Epibulbar masses | Colon lesions, peritoneum, soft tissue of chest wall | Excision | Unknown |
| Â | 41/F | OU | Epibulbar masses | Lung, aortic lymph nodes, pleura, skeletal (rib) | Steroid | Unknown |
Lee, 2018 (Present case) | 36/M | OS | Antecedent uveitis and anterior nodular scleritis, inferotemporal epibulbar mass | Facial skin nodule, multiple papulonodules on bilateral cheek, ear and scalp | Excision + Oral & topical steroid, methotrexate | No |