Clinical analysis of microbiologically proven fungal keratitis according to prior topical steroid use: a retrospective study in South Korea

Table 4 Risk factors for treatment failure^a in fungal keratitis using univariate and multivariate logistic regression analysis

Variables	Univariate analysis			Multivariate analysis^†
Variables	OR	95% CI	p-value	OR	95% CI	p-value
Female sex	1.27	0.50–3.23	0.620
Age ≥ 60 years	1.80	0.62–5.21	0.277
Agricultural occupation	0.48	0.18–1.25	0.130
Corneal trauma	0.22	0.08–0.66	0.006	-	-	-
Prior topical steroid use	2.99	1.14–7.84	0.026	2.79	0.85–9.18	0.091
Previous OSD	2.90	1.08–7.80	0.035	2.82	0.84–9.49	0.093
Previous herpetic keratitis	2.55	0.74–8.85	0.140
Previous ocular surgery	1.25	0.43–3.62	0.685
Diabetes mellitus	2.63	0.81–8.51	0.106
Symptom duration ≥10 days	1.34	0.52–3.46	0.543
Central corneal lesion	1.02	0.34–3.06	0.978
Epithelial defect size ≥10 mm²	2.56	0.98–6.70	0.055	-	-	-
Deep infiltration	8.34	2.90–23.96	< 0.001	4.38	1.37–14.08	0.013
Hypopyon	5.70	2.06–15.80	0.001	6.01	1.70–21.23	0.005
Presenting BCVA < 0.1, Snellen	4.85	1.60–14.67	0.005	-	-	-

BCVA best corrected visual acuity, CI confidence interval, OR odds ratio, OSD ocular surface disease;
^aTreatment failure was defined as the occurrence of complication or surgical intervention
^†Multivariate logistic regression analysis was performed using the backward-conditional method for the factors with a p-value < 0.1 in univariate logistic regression analysis

ISSN: 1471-2415