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Fig. 1 | BMC Ophthalmology

Fig. 1

From: Autophagy activated via GRP78 to alleviate endoplasmic reticulum stress for cell survival in blue light-mediated damage of A2E-laden RPEs

Fig. 1

Induction of ER stress-related cell death in blue light-mediated damage of A2E-laden RPEs. a: RPEs were incubated with 25 μM A2E for 2 h, then exposed to blue light for 20 min. At indicated time points, CHOP and caspase-12 protein levels were detected by western blot analysis. β-actin was used as the internal control. Bars represent the mean ± SD from three independent experiments (n = 3, *p < 0.05 versus control). b: TUNEL analysis was used to measure RPEs death at 12 h after A2E and blue light treatment (scale bar, 10 μm). The cell death rates are reported as percentage of TUNEL positive cells (n = 3, *p < 0.05).

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