Skip to main content

Table 2 Levels of 34 cytokines (means ± SD) in the aqueous humor among 3 groups

From: Comparison of cytokine levels in the aqueous humor of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration patients

cytokines

nAMD (pg/ml)

PCV (pg/ml)

Control (pg/ml)

P value (nAMD vs Control)

P value (PCV vs Control)

P value (nAMD vs PCV)

BDNF

4.58 ± 2.90

4.82 ± 2.83

18.69 ± 4.58

< 0.0001

< 0.0001

0.846

EGF

4.34 ± 2.65

4.07 ± 3.29

5.36 ± 2.72

0.403

0.208

0.807

Eotaxin

20.09 ± 3.96

17.64 ± 5.64

18.42 ± 6.03

0.449

0.671

0.221

GMCSF

31.62 ± 18.47

20.04 ± 17.93

40.07 ± 11.66

0.211

0.001

0.061

HGF

238.12 ± 113.63

325.59 ± 191.52

624.95 ± 165.93

< 0.0001

< 0.0001

0.165

IL-1RA

99.54 ± 31.25

89.35 ± 38.98

96.04 ± 37.40

0.815

0.593

0.453

IP-10

49.57 ± 36.70

33.44 ± 29.05

100.99 ± 38.55

< 0.0001

< 0.0001

0.195

MCP-1

61.57 ± 43.04

91.56 ± 88.82

274.24 ± 63.01

< 0.0001

< 0.0001

0.271

MIP-1α

8.91 ± 4.55

8.94 ± 5.46

8.72 ± 5.48

0.930

0.900

0.985

MIP-1β

50.91 ± 10.24

53.34 ± 17.27

55.47 ± 12.22

0.443

0.667

0.650

IL-2

0.32 ± 0.24

0.31 ± 0.24

0.32 ± 0.25

0.993

0.948

0.943

IL-4

0.03 ± 0.01

0.03 ± 0.01

0.03 ± 0.01

0.755

0.766

0.944

IL-5

0.07 ± 0.06

0.09 ± 0.05

0.08 ± 0.05

0.559

0.386

0.151

IL-6

0.72 ± 0.55

0.79 ± 0.48

0.96 ± 0.53

0.259

0.327

0.728

IL-8*

40.68 ± 35.47

14.63 ± 29.94

0.58 ± 0.60

0.053

0.012

0.012

IL-12p70*

2.89 ± 1.99

1.17 ± 1.67

3.49 ± 0.34

0.236

< 0.0001

0.029

IL-13

1.36 ± 1.26

2.25 ± 1.62

6.40 ± 1.58

< 0.0001

< 0.0001

0.120

IL-15

0.02 ± 0.01

0.02 ± 0.01

0.02 ± 0.01

0.553

0.835

0.642

IL-17A*

1.05 ± 0.60

1.30 ± 0.84

2.27 ± 1.65

0.008

0.008

0.370

IL-18*

40.98 ± 32.69

51.18 ± 37.16

0.41 ± 0.32

< 0.0001

< 0.0001

0.938

IL-21*

22.30 ± 20.41

14.78 ± 16.20

0.00 ± 0.00

< 0.0001

< 0.0001

0.243

IL-23

0.05 ± 0.02

0.03 ± 0.02

0.04 ± 0.03

0.622

0.182

0.078

IL-27

0.04 ± 0.03

0.05 ± 0.03

0.05 ± 0.03

0.802

0.980

0.764

IL-31*

10.11 ± 6.34

8.83 ± 5.13

0.17 ± 0.49

< 0.0001

< 0.0001

0.559

LIF*

87.17 ± 8.54

74.76 ± 36.89

14.33 ± 5.15

< 0.0001

< 0.0001

0.508

NGFβ

11.10 ± 6.64

9.78 ± 6.55

8.82 ± 5.09

0.365

0.646

0.562

PDGF-BB

1.90 ± 0.77

1.68 ± 0.88

1.62 ± 0.90

0.426

0.845

0.482

PIGF

0.28 ± 0.20

0.25 ± 0.14

0.26 ± 0.14

0.806

0.852

0.657

RANTES

4.49 ± 3.74

6.65 ± 4.26

4.23 ± 3.17

0.873

0.070

0.132

SCF*

5.75 ± 3.34

23.66 ± 3.34

5.89 ± 3.92

0.947

0.041

0.185

SDF1-α*

285.56 ± 73.64

273.10 ± 135.54

41.10 ± 10.58

< 0.0001

< 0.0001

0.755

FGF-basic*

0.11 ± 0.14

0.05 ± 0.10

0.00 ± 0.00

< 0.0001

0.001

0.031

VEGF-A*

175.71 ± 36.29

154.43 ± 87.56

38.69 ± 17.26

< 0.0001

< 0.0001

0.483

VEGF-D*

242.49 ± 28.96

221.50 ± 96.24

43.66 ± 23.61

< 0.0001

< 0.0001

0.459

  1. SD = Standard deviation. IL = Interleukin, LIF = leukemia inhibitory factor, SDF1-α = stromal-derived factor 1-α, BDNF = brain-derived neurotrophic factor, IP-10 = interferon inducible protein 10, HGF = hepatocyte Growth Factor, IL-12p70 = interleukin-12p70, PIGF = placental growth factor, FGF-basic = basic fibroblast growth factor, GMCSF = granulocyte macrophage colony stimulating Factor, EGF = epidermal growth factor, MIP-1β = macrophage inflammatory protein 1β, RANTES = regulated upon the activation of normal T cell expressed and secreted, PDGF-BB = platelet-derived growth factor-BB, MCP-1 = monocyte chemoattractant protein, NGFb = nerve growth factor b, SCF = stem cell factor, MIP-1α = macrophage inflammatory protein-1α, GROα = growth-related gene product α, IFNγ = interferon-γ, IFNα = interferon-α, TNF = tumor necrosis factor. Bold = P value was statistically significant(P < 0.05 was deemed to be statistically significant which using ANOVA test when data meet normal distribution, while * means unnormal distribution including IL-8, IL-12p70, IL-17A, IL-18, IL-21, IL-31, LIF, SCF, SDF1-α, FGF-basic, VEGF-A and VEGF-D using Mann-Whitney test which P < 0.0167 was deemed to be statistically significant)