Variables | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
Unadjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | |
Age group, years | ||||
  < 60 | Reference |  | Reference |  |
 60–75 | 1.02 (0.76–1.39) | 0.86 | 1.01 (0.75–1.38) | 0.91 |
  ≥ 75 | 1.17 (0.86–1.61) | 0.31 | 1.09 (0.76–1.58) | 0.62 |
Sex (male vs. female) | 0.84 (0.65–1.09) | 0.19 | 0.82 (0.63–1.07) | 0.14 |
Number of injections | ||||
 First level (< 10) | Reference |  | Reference |  |
 Second level (10–15) | 1.75 (1.21–2.53) | < 0.01 | 1.91 (1.32–2.76) | < 0.001 |
 Third level (≥15) | 1.99 (1.28–3.08) | < 0.01 | 2.20 (1.42–3.43) | < 0.001 |
Diabetes | 1.82 (1.36–2.44) | < 0.0001 | 2.03 (1.46–2.81) | < 0.0001 |
Hyspertension | 1.05 (0.83–1.35) | 0.65 | 1.04 (0.85–1.30) | 0.65 |
Hyperlipidemia | 1.27 (0.95–1.70) | 0.11 | 1.04 (0.75–1.43) | 0.83 |
Ischemic heart disease | 1.16 (0.85–1.58) | 0.35 | 1.20 (0.86–1.67) | 0.29 |
Glaucoma | 1.43 (1.01–2.03) | < 0.05 | 1.35 (0.95–1.92) | 0.09 |