Fig. 2From: Markedly increased ocular side effect causing severe vision deterioration after chemotherapy using new or investigational epidermal or fibroblast growth factor receptor inhibitorsAnterior segment photographs of patients on vandetanib and osimertinib. Corneal photographs of case 2 taken at 419 days after the start of chemotherapy with vandetanib. a Both corneas showed dense cornea verticillata on the central part (yellow arrows Δ). b Under fluorescein staining, no corneal epithelial defects were found. Corneal photographs of case 4 taken at 305 days after start of chemotherapy with osimertinib. c Vortex keratopathy with a whorl-like pattern was prominent, especially on the patient’s right cornea (yellow arrows Δ). d Under fluorescein staining, no corneal epithelial defects were foundBack to article page