Markedly increased ocular side effect causing severe vision deterioration after chemotherapy using new or investigational epidermal or fibroblast growth factor receptor inhibitors

Table 1 Ocular complications of patients who underwent EGFR of FGFR inhibitors chemotherapy

	External adnexa					Internal Adnexa			non specificⁱ	Total
	orbit^a	eyelid^b	sclera / conjunctiva^c	extraocular muscles^d	cornea^e	lens^f	vitreous/retina^g	optic disc^h	non specificⁱ	Total
Disease-unrelated	5	107	29	48	101	189	215	118	300	1112
Disease-related	5	–	–	–	–	–	28	–	–	33
Treatment-related	–	–	–	–	13	–	3	–	–	16
Total	10	107	29	48	114	189	246	118	300	1161

Patients were categorized into three groups and subdivided according to their clinical diagnosis. Three groups were 'Disease-unrelated', 'Disease-related' and 'Treatment-related' group
^aDisease-unrelated (blow out fracture), Disease-related (orbit metastasis)
^bDisease-unrelated (meibomian gland dysfunction, blepharitis, nasolacrimal duct obstruction, ptosis, dermatochalasis, cellulitis, eyelid cancer, entropion, chlazion, trichiasis)
^cDisease-unrelated (allergic conjunctivitis, viral conjunctivitis)
^dDisease-unrelated (strabismus)
^eDisease-unrelated (dry eye syndrome, opacity, scar, pseudophakic bullous keraopathy, dystrophy, herpetic keratitis, exposure keratitis, epidermic keratoconjuncitivitis), Treatment-related (corneal epithelial changes, corneal ulcer)
^fDisease-unrelated (cataract)
^gDisease-unrelated (diabetic retinopathy, macular hole, epiretinal membrance, myopic tractional maculopathy, central serous chorioretinopathy, retinal detachmentage related macular degeneration, vitreous floater, endophthalmitis), Disease related (choroidal metastasis), Treatment-related (radiation retinopathy)
^hDisease-unrelated (glaucoma, optic neuropathy, visual field defect)
ⁱThis category includes patients who had regular ophthalmologic examination without any specific lesions

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