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Table 1 Ocular complications of patients who underwent EGFR of FGFR inhibitors chemotherapy

From: Markedly increased ocular side effect causing severe vision deterioration after chemotherapy using new or investigational epidermal or fibroblast growth factor receptor inhibitors

 External adnexaInternal Adnexanon specificiTotal
orbitaeyelidbsclera / conjunctivacextraocular musclesdcorneaelensfvitreous/retinagoptic disch
Disease-unrelated510729481011892151183001112
Disease-related52833
Treatment-related13316
Total1010729481141892461183001161
  1. Patients were categorized into three groups and subdivided according to their clinical diagnosis. Three groups were 'Disease-unrelated', 'Disease-related' and 'Treatment-related' group
  2. aDisease-unrelated (blow out fracture), Disease-related (orbit metastasis)
  3. bDisease-unrelated (meibomian gland dysfunction, blepharitis, nasolacrimal duct obstruction, ptosis, dermatochalasis, cellulitis, eyelid cancer, entropion, chlazion, trichiasis)
  4. cDisease-unrelated (allergic conjunctivitis, viral conjunctivitis)
  5. dDisease-unrelated (strabismus)
  6. eDisease-unrelated (dry eye syndrome, opacity, scar, pseudophakic bullous keraopathy, dystrophy, herpetic keratitis, exposure keratitis, epidermic keratoconjuncitivitis), Treatment-related (corneal epithelial changes, corneal ulcer)
  7. fDisease-unrelated (cataract)
  8. gDisease-unrelated (diabetic retinopathy, macular hole, epiretinal membrance, myopic tractional maculopathy, central serous chorioretinopathy, retinal detachmentage related macular degeneration, vitreous floater, endophthalmitis), Disease related (choroidal metastasis), Treatment-related (radiation retinopathy)
  9. hDisease-unrelated (glaucoma, optic neuropathy, visual field defect)
  10. iThis category includes patients who had regular ophthalmologic examination without any specific lesions
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