Fig. 4From: Mutation screening of the USH2A gene reveals two novel pathogenic variants in Chinese patients causing simplex usher syndrome 2a Schematic illustration of the exon pathogenic variants identified in this study along the USH2A isoform b protein domains. SP: signal peptide; Lam GL: Laminin G-like domain; Lam NT: Laminin N-terminal; EGF Lam: EGF-like domain; FN3: fibronectin type-III; LamG: Laminin G domain; TM: transmembrane region; PDB: PDZ-binding domain b Amino acid sequence alignments obtained by Clustal Omega software. Exon missense mutations in this study p.Trp2744Cys (c.8232G > C) and p.Asp3927Gly (c.11780A > G) in Human USH2A gene aligned with other species including Troglodyte, Zebrafish, Chicken, Mulatta, Mouse and BovineBack to article page