Effect of corneal cross-linking on endothelial cell density and morphology in the peripheral cornea

BMC Ophthalmology

Table 3 Previous studies on the long-term (spanning more than 2 years) changes in the central ECD loss, and those on the changes in the central CV and HEX after CXL

Author	Year	Eyes	Follow-up	Surgical Method	ECD loss (%)	CV, HEX (%)	Location	Device
Vinciguerra P et al. [11]	2009	28	2Y	Standard	4.9	N.A.	Center	Unknown (Konan)
Caporossi A et al. [12]	2010	44	4Y	Standard	0.7	N.A.		Noncon ROBO V (Konan)
Spada L et al. [13]	2012	16	1Y	Trans-epithelial	0.5	CV 28 to 29		SP-500 (SEED)
Kymionis GD et al. [10]	2014	25	5Y	Standard	3.6	N.A.		EM-3000 (TOMEY)
Wittig-silva C et al. [14]	2014	46	3Y	Standard	2.5	N.A.		SP-2000 (Topcon)
Cingü AK et al. [15]	2014	36	6 M	Accelerated	0.7	CV 44 to 46		Noncon ROBO SP-6000 (Konan)
Cingü AK et al. [15]	2014	36	6 M	Accelerated	0.7	HEX 45 to 44		Noncon ROBO SP-6000 (Konan)
Goldich Y et al. [16]	2014	17	3Y	Standard	7.5	N.A.		Noncon ROBO SP-6000 (Konan)
Nasrollahi K et al. [17]	2015	140	1Y	Standard	1.5	CV 39 to 40		Unknown (TOMEY)
Nasrollahi K et al. [17]	2015	140	1Y	Standard	1.5	HEX 54 to 53		Unknown (TOMEY)
Sedaghat M et al. [18]	2015	97	1Y	Standard	3.3	CV 18 to 20		SP-2000 (Topcon)
Sadoughi MM et al. [19]	2016	15	1Y	Standard	1.5	CV 34 to 35		SP-2000 (Topcon)
Sadoughi MM et al. [19]	2016	15	1Y	Standard	1.5	HEX 56 to 57		SP-2000 (Topcon)
Giacomin NT et al. [20]	2016	40	4Y	Standard	−0.1	N.A.		Unknown (Konan)
Badawi AE et al. [21]	2016	40	1Y	Accelerated	0.9	CV 35 to 36		EM-3000 (TOMEY)
Badawi AE et al. [21]	2016	40	1Y	Accelerated	0.9	HEX 55 to 56		EM-3000 (TOMEY)
Current		31	6 M	Standard	1.2*	CV 41 to 42*	Periphery	EM-3000 (TOMEY)
Current		31	6 M	Standard	1.2*	HEX 33 to 33*	Periphery	EM-3000 (TOMEY)

M Month, Y Year, ECD Endothelial cell density, CV Coefficient of variation, HEX = percentage of hexagonal cells, CXL Corneal crosslinking. *The average data of 6 peripheral measurement points

ISSN: 1471-2415