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Table 3 Previous studies on the long-term (spanning more than 2 years) changes in the central ECD loss, and those on the changes in the central CV and HEX after CXL

From: Effect of corneal cross-linking on endothelial cell density and morphology in the peripheral cornea

AuthorYearEyesFollow-upSurgical MethodECD loss (%)CV, HEX (%)LocationDevice
Vinciguerra P et al. [11]2009282YStandard4.9N.A.CenterUnknown
(Konan)
Caporossi A et al. [12]2010444YStandard0.7N.A.Noncon ROBO V
(Konan)
Spada L et al. [13]2012161YTrans-epithelial0.5CV 28 to 29SP-500
(SEED)
Kymionis GD et al. [10]2014255YStandard3.6N.A.EM-3000
(TOMEY)
Wittig-silva C et al. [14]2014463YStandard2.5N.A.SP-2000
(Topcon)
Cingü AK et al. [15]2014366 MAccelerated0.7CV 44 to 46Noncon ROBO SP-6000
(Konan)
HEX 45 to 44
Goldich Y et al. [16]2014173YStandard7.5N.A.Noncon ROBO SP-6000
(Konan)
Nasrollahi K et al. [17]20151401YStandard1.5CV 39 to 40Unknown
(TOMEY)
HEX 54 to 53
Sedaghat M et al. [18]2015971YStandard3.3CV 18 to 20SP-2000
(Topcon)
Sadoughi MM et al. [19]2016151YStandard1.5CV 34 to 35SP-2000
(Topcon)
HEX 56 to 57
Giacomin NT et al. [20]2016404YStandard−0.1N.A.Unknown
(Konan)
Badawi AE et al. [21]2016401YAccelerated0.9CV 35 to 36EM-3000
(TOMEY)
HEX 55 to 56
Current 316 MStandard1.2*CV 41 to 42*PeripheryEM-3000
(TOMEY)
HEX 33 to 33*
  1. M Month, Y Year, ECD Endothelial cell density, CV Coefficient of variation, HEX = percentage of hexagonal cells, CXL Corneal crosslinking. *The average data of 6 peripheral measurement points