Fig. 3

Representative images of patients who received intravitreal injections of ranibizumab (IVR) under “1 + PRN” regimen. a-d were optical coherence tomography (OCT) images for case 1 at the time-points of baseline, month 3, month 6, and month 12, respectively. Case 1 had a best-corrected visual acuity (BCVA) of 0.3 and intact of external limiting membrane (ELM) and ellipsoid zone (EZ) at baseline (a). The subretinal fluid was absorbed immediately after one injection of ranibizumab, and the BCVA increased to 0.6 at month 1. No additional injection was needed for case 1, and the macular remained dry with the BCVA increased to 0.8 at month 12 (b-d). (E-H) were OCT images for case 2 at baseline, month 3, month 6, and month 12, respectively. Please note that case 2 had a disrupted ELM and EZ with a BCVA of 0.1 at baseline (e). Intraretinal fluid was partially absorbed after three injections of ranibizumab (f). Case 2 continued to receive another three injections of ranibizumab monthly and then intraretinal fluid was totally absorbed at month 6 (g). After a total of 6 times IVR under “1 + PRN” regimen the intraretinal fluid was totally absorbed, however, the BCVA was still 0.1 at month 12