Fig. 1

Images of the bulbar conjunctiva in a normal subject and a patient using multiple glaucoma eye drops. a, d Image from iris viewpoint. The anterior segment scan (solid yellow line) was performed at the superior conjunctiva. White arrowheads in C and F indicates the corneal limbus defined by the intersection of the perpendicular line from the angle with the ocular surface. a-c Images obtained from a patient without anti-glaucoma eye drops (65-year-old man). A continuous, narrow, low reflectivity surface layer (conjunctival epithelium [CE]) was present. Below the conjunctival epithelial layer, a highly reflective layer (conjunctival stroma [CS]) was separated from the underlying low reflectivity layer (Tenon’s capsule [T]). The sclera can be observed as a highly reflective region beneath Tenon’s capsule. Red, blue, and yellow lines indicate the borderlines of the conjunctival epithelium/stroma, stroma/Tenon’s capsule, and Tenon’s capsule/sclera, respectively. d-f Images obtained from a glaucoma patient (63-year-old man) with multiple anti-glaucoma eye drops (prostaglandin analog + a combination of β-blocker/CAI). The disruption of the bulbar conjunctival borderlines of both the stroma/Tenon’s capsule and Tenon’s capsule/sclera was observed, but the borderlines of the conjunctival epithelium/conjunctival stroma were preserved